1256360-50-5

Usage

Uses

Used in Medicinal Chemistry:
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydroquinoline is used as a building block for the synthesis of new compounds in medicinal chemistry. Its boron-containing cyclic group and tetrahydroquinoline core provide unique reactivity and biological activity, making it a valuable component in the development of pharmaceuticals with potential therapeutic applications.
Used in Drug Development:
In the pharmaceutical industry, 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydroquinoline is used as a precursor for the creation of novel drugs. 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydroquinoline's stability and the presence of a boron atom make it suitable for further chemical modifications and the exploration of its potential in treating various diseases and medical conditions.
Used in Biomedical Research:
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydroquinoline is utilized in biomedical research as a model compound to study the interactions between boron-containing compounds and biological systems. Its tetrahydroquinoline structure, which is found in various biologically active compounds, allows researchers to investigate its potential role in biological processes and its effects on cellular functions.
Overall, 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydroquinoline is a versatile chemical compound with potential applications in medicinal chemistry, drug development, and biomedical research. Its unique structure and properties make it an interesting candidate for further exploration and development in the scientific community.

Upstream product

• 10500-57-9 5,6,7,8-tetrahydroquinoline 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 82132-68-1 3-bromo-5,6,7,8-tetrahydroquinoline 
• 904929-24-4 3-bromo-6,7-dihydroguinolin-8(5H)-one 
• 1260536-88-6 2-((trans-4-hydroxycyclohexyl)amino)-4-(3-isopropyl-4-(5,6,7,8-tetrahydroquinolin-3-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)benzonitrile 

Relevant academic research and scientific papers

Competent Route to Unsymmetric Dimer Architectures: Total Syntheses of (?)-Lycodine and (?)-Complanadines A and B, and Evaluation of Their Neurite Outgrowth Activities

Valuable synthetic routes to the Lycopodium alkaloid lycodine (1) and its unsymmetric dimers, complanadines A (4) and B (5), have been developed. Regioselective construction of the bicyclo[3.3.1]nonane core structure of lycodine was achieved by a remote functionality-controlled Diels–Alder reaction and subsequent intramolecular Mizoroki–Heck reaction. A key coupling reaction of the lycodine units, pyridine N-oxide (66) and aryl bromide (65), through C?H arylation at the C1 position of 66 provided the unsymmetric dimer structure at a late stage of the synthesis. This strategy greatly simplified the construction of the dimeric architecture and functionalization. Complanadines A (4) and B (5) were synthesized by adjusting the oxidation level of the bipyridine mono-N-oxide (67). The diverse utility of this common intermediate (67) suggests a possible biosynthetic pathway of complanadines in Nature. Both enantiomers of lycodine (1) and complanadines A (4) and B (5) were prepared in sufficient quantities for biological evaluation. The effect on neuron differentiation of PC-12 cells upon treatment with culture medium, in which human astrocytoma cells had been cultured in the presence of 1, 4, or 5 was evaluated.

Cyclic gyrase and topoisomerase IV inhibitor

The invention belongs to the technical field of medicament, and particularly relates to a compound shown in formula (I) (please see the formula (I) in the description), and acceptable salt, ester or stereoisomer of the compound in pharmacy. R1, R2, a ring

Total syntheses of complanadines A and B

Twice as nice: Total syntheses of dimeric alkaloids, (-)-complanadines A (1) and B (2), were achieved from (-)-lycodine. The unsymmetrical motif was assembled through direct arylation of the pyridine N-oxide. The absolute configuration and specific rotations of complanadines A and B were identified. Cbz=Benzyloxycarbonyl. Copyright