82132-68-1

Usage

Uses

Used in Pharmaceutical Industry:
QUINOLINE, 3-BROMO-5,6,7,8-TETRAHYDROis used as a key intermediate in the synthesis of various pharmaceuticals for the development of new drugs to treat a range of diseases. Its unique chemical structure allows for the creation of diverse drug candidates with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic chemistry, QUINOLINE, 3-BROMO-5,6,7,8-TETRAHYDROis utilized as a versatile building block for the synthesis of complex organic molecules. Its presence in the molecular structure enables the formation of a variety of compounds with different functional groups and properties, expanding the scope of organic synthesis.
Used in Medicinal Chemistry Research:
QUINOLINE, 3-BROMO-5,6,7,8-TETRAHYDROis employed as a valuable research tool in medicinal chemistry. It aids scientists in understanding the structure-activity relationships of various drug candidates and contributes to the discovery of novel therapeutic agents with improved efficacy and safety profiles.

Upstream product

• 15295-69-9 hept-6-ynenitrile 
• 82132-55-6 2,3-Bis-trimethylsilanyl-5,6,7,8-tetrahydro-quinoline 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 114078-88-5 5-bromo-1,2,3-triazine 
• 10500-57-9 5,6,7,8-tetrahydroquinoline 
• 1256360-50-5 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydroquinoline 

Downstream Products

• 904929-24-4 3-bromo-6,7-dihydroguinolin-8(5H)-one 
• 1059063-56-7 C₂₂H₂₂ClFN₄O 

Relevant academic research and scientific papers

Competent Route to Unsymmetric Dimer Architectures: Total Syntheses of (?)-Lycodine and (?)-Complanadines A and B, and Evaluation of Their Neurite Outgrowth Activities

Valuable synthetic routes to the Lycopodium alkaloid lycodine (1) and its unsymmetric dimers, complanadines A (4) and B (5), have been developed. Regioselective construction of the bicyclo[3.3.1]nonane core structure of lycodine was achieved by a remote functionality-controlled Diels–Alder reaction and subsequent intramolecular Mizoroki–Heck reaction. A key coupling reaction of the lycodine units, pyridine N-oxide (66) and aryl bromide (65), through C?H arylation at the C1 position of 66 provided the unsymmetric dimer structure at a late stage of the synthesis. This strategy greatly simplified the construction of the dimeric architecture and functionalization. Complanadines A (4) and B (5) were synthesized by adjusting the oxidation level of the bipyridine mono-N-oxide (67). The diverse utility of this common intermediate (67) suggests a possible biosynthetic pathway of complanadines in Nature. Both enantiomers of lycodine (1) and complanadines A (4) and B (5) were prepared in sufficient quantities for biological evaluation. The effect on neuron differentiation of PC-12 cells upon treatment with culture medium, in which human astrocytoma cells had been cultured in the presence of 1, 4, or 5 was evaluated.

Cyclic gyrase and topoisomerase IV inhibitor

The invention belongs to the technical field of medicament, and particularly relates to a compound shown in formula (I) (please see the formula (I) in the description), and acceptable salt, ester or stereoisomer of the compound in pharmacy. R1, R2, a ring

Total syntheses of complanadines A and B

Twice as nice: Total syntheses of dimeric alkaloids, (-)-complanadines A (1) and B (2), were achieved from (-)-lycodine. The unsymmetrical motif was assembled through direct arylation of the pyridine N-oxide. The absolute configuration and specific rotations of complanadines A and B were identified. Cbz=Benzyloxycarbonyl. Copyright

Inverse electron demand diels-alder reactions of 1,2,3-triazines: Pronounced substituent effects on reactivity and cycloaddition scope

A systematic study of the inverse electron demand Diels-Alder reactions of 1,2,3-triazines is disclosed, including an examination of the impact of a C5 substituent. Such substituents were found to exhibit a remarkable impact on the cycloaddition reactivity of the 1,2,3-triazine without altering, and perhaps even enhancing, the intrinsic cycloaddition regioselectivity. The study revealed not only that the reactivity may be predictably modulated by a C5 substituent (R = CO2Me > Ph > H) but also that the impact is of a magnitude to convert 1,2,3-triazine (1) and its modest cycloaddition scope into a heterocyclic azadiene system with a reaction scope that portends extensive synthetic utility, expanding the range of participating dienophiles. Significantly, the studies define a now powerful additional heterocyclic azadiene, complementary to the isomeric 1,2,4-triazines and 1,3,5-triazines, capable of dependable participation in inverse electron demand Diels-Alder reactions, extending the number of complementary heterocyclic ring systems accessible with implementation of the methodology.

N-aryl-piperazinealkanamides useful for improving sleep

A method of improving sleep in warm-blooded animals suffering from sleep disorders, which method comprises the administration of particular N-aryl-piperazinealkanamide derivatives and compositions containing the same. Novel N-aryl-piperazinealkanamide derivatives.

Catalytic Co-cyclisation of α,ω-Cyanoalkynes with Alkynes: a Versatile Chemo- and Regio-selective Synthesis of 2,3-Substituted 5,6,7,8-Tetrahydroquinolines and other Cycloalkapyridines

α,ω-Cyanoalkynes are catalytically cocyclised with alkynes in the presence of dicarbonyl(cyclopentadienyl)cobalt to furnish annulated pyridines chemo- and regio-selectively.