1256388-47-2

Basic information

• Product Name: Ledipasvir interMediate
• Synonyms: Ledipasvir interMediate;(S)-5-((Benzyloxy)carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(phenylmethyl) ester;N-Cbz-4-cyclopropyl-(L)-proline;(6S)-5-[(benzyloxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid;(S)-5-CBZ-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID
• CAS NO: 1256388-47-2
• Molecular Formula: C₁₅H₁₇NO₄
• Molecular Weight: 275.29978
• EINECS: -0
• Mol File: 1256388-47-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ledipasvir interMediate(CAS DataBase Reference)
• NIST Chemistry Reference: Ledipasvir interMediate(1256388-47-2)
• EPA Substance Registry System: Ledipasvir interMediate(1256388-47-2)

Safety Data

• Hazardous Substances Data: 1256388-47-2(Hazardous Substances Data)

Usage

General Description

Ledipasvir intermediate is a chemical compound used in the synthesis of ledipasvir, a medication used in the treatment of chronic hepatitis C. This intermediate acts as a building block in the production of ledipasvir, and it undergoes several chemical reactions to eventually form the final drug product. Ledipasvir intermediate is a key component in the manufacturing process of ledipasvir, and its purity and quality are critical in ensuring the efficacy and safety of the final medication. It is an important chemical in the pharmaceutical industry, playing a vital role in the production of a medication that helps to improve the lives of patients with chronic hepatitis C.

Upstream product

• 1129634-44-1 (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid 
• 501-53-1 benzyl chloroformate 
• 2370-38-9 4-methylene-pyrrolidine-2-carboxylic acid 
• 144539-45-7 4-methylene-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 1256388-46-1 (S)-N-benzyloxycarbonyl-5-azaspiro[2.4]heptane-6-carboxylic acid methyl ester 
• 200184-60-7 (S)-N-benzyloxycarbonyl-4-methylenepyrrolidine-2-carboxylic acid methyl ester 
• 84348-38-9 (S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid 

Downstream Products

• 1256388-48-3 5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester 

Relevant articles and documents

A class of heterocyclic peptide deformylase inhibitors and its preparation method and application

The invention discloses a heterocyclic peptide deformylase inhibitors and its preparation method and application. The inhibitor of the formula (I) structure shown; wherein A is five Yuan azo aryl heterocyclic, X, Y, Z are each independently C, O, S or N, the R is a single substituent, multi-substituent or with ring A. The invention [...] formyl enzyme inhibitor of novel structure, better activity, toxicity is small, for gram positive and gram-negative leaching showed significantly inhibit function, even with respect to a multiple drug-resistant bacteria, also has excellent inhibition; at the same time, the compound of the colorectal cancer, lung cancer and osteosarcoma tumor cell also have obvious inhibition, can inhibit the proliferation of tumor cells, may be prepared into antibacterial drug or anti-tumor drug on application.

5 - azaspiro [2.4] heptane - 6 - carboxylic acid derivatives of the synthesis method (by machine translation)

The present invention provides a (5S) - 5 - azaspiro [2.4] heptane - 6 - carboxylic acid derivatives of the synthetic method, in order to 1, 1 - cyclopropane dicarboxylic alcohol as the starting material, the reaction with thionyl chloride, is oxidized and get sulfonic acid ester compound, then with glycine methyl ester imine under the action of the tertiary butyl alcohol potassium condensation, again through the system acidic, alkaline methylsulphonyl complete hydrolysis, cyclization, amino protection of the racemic product, finally split to obtain the finished product, the total yield up to 30% or more, the reaction route step is short, reagent used in the security, the operation is simple, of low cost, high yield, suitable for industrial production. (by machine translation)

METHODS FOR TREATING HCV

This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.