1256388-47-2

Usage

Uses

Used in Pharmaceutical Industry:
Ledipasvir intermediate is used as a key component in the synthesis of ledipasvir for the treatment of chronic hepatitis C. It plays a critical role in the manufacturing process, ensuring the production of a medication that effectively addresses the health needs of patients with this chronic condition.
Used in Medication Production:
Ledipasvir intermediate is used as a precursor in the chemical reactions that lead to the formation of the final drug product, ledipasvir. Its presence is essential for the successful synthesis of the medication, which is specifically formulated to combat chronic hepatitis C and improve patient outcomes.

Upstream product

• 84348-38-9 (S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid 
• 200184-60-7 (S)-N-benzyloxycarbonyl-4-methylenepyrrolidine-2-carboxylic acid methyl ester 
• 501-53-1 benzyl chloroformate 
• 1256388-46-1 (S)-N-benzyloxycarbonyl-5-azaspiro[2.4]heptane-6-carboxylic acid methyl ester 
• 144539-45-7 4-methylene-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 2370-38-9 4-methylene-pyrrolidine-2-carboxylic acid 
• 1129634-44-1 (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid 

Downstream Products

• 1256388-48-3 5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester 

Relevant academic research and scientific papers

A class of heterocyclic peptide deformylase inhibitors and its preparation method and application

The invention discloses a heterocyclic peptide deformylase inhibitors and its preparation method and application. The inhibitor of the formula (I) structure shown; wherein A is five Yuan azo aryl heterocyclic, X, Y, Z are each independently C, O, S or N, the R is a single substituent, multi-substituent or with ring A. The invention [...] formyl enzyme inhibitor of novel structure, better activity, toxicity is small, for gram positive and gram-negative leaching showed significantly inhibit function, even with respect to a multiple drug-resistant bacteria, also has excellent inhibition; at the same time, the compound of the colorectal cancer, lung cancer and osteosarcoma tumor cell also have obvious inhibition, can inhibit the proliferation of tumor cells, may be prepared into antibacterial drug or anti-tumor drug on application.

Compound as apoptosis protein inhibitor, and application thereof

The present invention belongs to the field of medical chemistry, relates to a class of compounds of apoptosis protein inhibitors, and applications thereof, and particularly provides a compound represented by a formula I, or an isomer thereof, a pharmaceut

5 - azaspiro [2.4] heptane - 6 - carboxylic acid derivatives of the synthesis method (by machine translation)

The present invention provides a (5S) - 5 - azaspiro [2.4] heptane - 6 - carboxylic acid derivatives of the synthetic method, in order to 1, 1 - cyclopropane dicarboxylic alcohol as the starting material, the reaction with thionyl chloride, is oxidized and get sulfonic acid ester compound, then with glycine methyl ester imine under the action of the tertiary butyl alcohol potassium condensation, again through the system acidic, alkaline methylsulphonyl complete hydrolysis, cyclization, amino protection of the racemic product, finally split to obtain the finished product, the total yield up to 30% or more, the reaction route step is short, reagent used in the security, the operation is simple, of low cost, high yield, suitable for industrial production. (by machine translation)

METHODS FOR TREATING HCV

This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

METHODS FOR TREATING HCV

This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.