1256388-48-3

Basic information

• Product Name: 5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester
• Synonyms: 5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester
• CAS NO: 1256388-48-3
• Molecular Weight: 596.425
• Mol File: 1256388-48-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester(1256388-48-3)
• EPA Substance Registry System: 5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester(1256388-48-3)

Safety Data

• Hazardous Substances Data: 1256388-48-3(Hazardous Substances Data)

Upstream product

• 84348-38-9 (S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid 
• 501-53-1 benzyl chloroformate 
• 1256388-46-1 (S)-N-benzyloxycarbonyl-5-azaspiro[2.4]heptane-6-carboxylic acid methyl ester 
• 1229603-71-7 2,7-dibromo-9,9-difluoro-9H-fluorene 
• 1256388-47-2 (S)-5-((benzyloxy)carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 14348-75-5 2,7-dibromofluorene-9-one 
• 144539-45-7 4-methylene-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 2370-38-9 4-methylene-pyrrolidine-2-carboxylic acid 
• 1378387-81-5 1-(7-bromo-9,9-difluoro-9-hydrofluoren-2-yl)-2-chloroethanone 

Downstream Products

• 1256393-27-7 3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 1256388-49-4 6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester 
• 1256388-50-7 (1-{6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester 

Relevant articles and documents

METHOD OF PREPARATION FOR LEDIPASVIR AND DERIVATIVE THEREOF, AND INTERMEDIATE COMPOUND FOR PREPARATION OF LEDIPASVIR

Methods of preparing Ledipasvir and derivatives thereof, and intermediate compounds used in the preparation of Ledipasvir are provided. Specifically, a method for preparing the compounds of formula 1 and a series of preparation methods of preparing Ledipasvir are provided. The methods described herein are simple and efficient, and have better application prospects.

METHODS FOR TREATING HCV

This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.