1256388-50-7

Basic information

• Product Name: ledipasvir interMediate
• Synonyms: Methyl (S)-1-((S)-6-(5-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-1H-iMidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-Methyl-1-oxobutan-2-ylcarbaMate;CarbaMic acid, N-[(1S)-1-[[(6S)-6-[5-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-1H-iMidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-Methylpropyl]-, Methyl ester;N-[(1S)-1-[[(6S)-6-[5-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-methylpropyl]carbamic acid methyl ester;N-[(1S)-1-[[(6S)-6-[5-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-methylpropyl]carbamic acid methyl
• CAS NO: 1256388-50-7
• Molecular Formula: C₂₉H₂₉BrF₂N₄O₃
• Molecular Weight: 599.4663664
• EINECS: -0
• Mol File: 1256388-50-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 789.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• PKA: 11.13±0.10(Predicted)
• CAS DataBase Reference: ledipasvir interMediate(CAS DataBase Reference)
• NIST Chemistry Reference: ledipasvir interMediate(1256388-50-7)
• EPA Substance Registry System: ledipasvir interMediate(1256388-50-7)

Safety Data

• Hazardous Substances Data: 1256388-50-7(Hazardous Substances Data)

Usage

General Description

Ledipasvir intermediate refers to a chemical compound that is used in the synthesis of ledipasvir, a medication used to treat chronic hepatitis C infections. This intermediate compound serves as a crucial building block in the production of ledipasvir and is an essential component in the overall chemical synthesis process. The synthesis of ledipasvir intermediate involves several chemical reactions and purification steps to ensure the compound's purity and quality. Ledipasvir intermediate plays a critical role in the pharmaceutical industry, contributing to the production of a medication that has led to significant advancements in the treatment of hepatitis C infections.

Upstream product

• 1296797-09-5 C₁₄H₂₂N₂O₅ 
• 1441670-89-8 (6S)-6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]heptane-5-carboxylic acid 1,1-dimethylethyl ester 
• 111398-44-8 N-methoxycarbonyl-L-valine 
• 111398-44-8 (2R)-2-(methoxycarbonyl amino)-3-methylbutanoic acid 
• 1446396-65-1 2-(L)-methoxycarbonylamino-3-methylbutyric acid 
• 1256388-49-4 6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester 
• 1256388-48-3 5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester 
• 14348-75-5 2,7-dibromofluorene-9-one 
• 1229603-71-7 2,7-dibromo-9,9-difluoro-9H-fluorene 

Downstream Products

• 1256388-51-8 methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]-hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate 
• 1256393-27-7 3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

METHOD OF PREPARATION FOR LEDIPASVIR AND DERIVATIVE THEREOF, AND INTERMEDIATE COMPOUND FOR PREPARATION OF LEDIPASVIR

Methods of preparing Ledipasvir and derivatives thereof, and intermediate compounds used in the preparation of Ledipasvir are provided. Specifically, a method for preparing the compounds of formula 1 and a series of preparation methods of preparing Ledipasvir are provided. The methods described herein are simple and efficient, and have better application prospects.

METHODS FOR TREATING HCV

This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.