125643-35-8Relevant academic research and scientific papers
Radical-Mediated Heck-Type Alkylation: Stereoconvergent Synthesis of Functionalized Polyenes
Zhang, Hong,Wu, Xinxin,Wei, Yunlong,Zhu, Chen
supporting information, p. 7568 - 7572 (2019/10/02)
The stereospecific synthesis of polyenes is of great synthetic value. Disclosed herein is a new, efficient, stereoconvergent approach for the synthesis of functionalized polyenes via a radical-mediated Heck-type alkylation. The easily accessed Z- and E-mixed alkenes are harnessed as starting material, leading to a unique stereoisomer of polyenes. In addition, the transformation features mild reaction conditions and broad functional group compatibility. A variety of valuable 1,3-dienes and 1,3,5-trienes are afforded in useful yields.
Copper-catalyzed pyrrole synthesis from 3,6-dihydro-1,2-oxazines
Yasukawa, Naoki,Kuwata, Marina,Imai, Takuya,Monguchi, Yasunari,Sajiki, Hironao,Sawama, Yoshinari
supporting information, p. 4409 - 4413 (2018/10/17)
Highly-functionalized pyrroles could be effectively synthesized from 3,6-dihydro-1,2-oxazines using a heterogeneous copper on carbon (Cu/C) under neat heating conditions. Furthermore, the in situ formation of 3,6-dihydro-1,2-oxazines via the hetero Diels-Alder reaction between nitroso dienophiles and 1,3-dienes and the following Cu/C-catalyzed pyrrole synthesis also provided the corresponding pyrrole derivatives in a one-pot manner.
A visible-light-mediated oxidative C-N bond formation/aromatization cascade: Photocatalytic preparation of N-arylindoles
Maity, Soumitra,Zheng, Nan
supporting information, p. 9562 - 9566 (2012/11/07)
Just add light and air: Structurally diverse N-arylindoles can be prepared from readily prepared o-styryl anilines through visible-light photocatalysis. The reaction, which is conducted open to air, is mediated by [Ru(bpz) 3](PF6)2 (bpz=2,2'-bipyrazine) and involves both C-N bond formation and aromatization (see scheme). Using suitably substituted substrates, a 1,2-carbon shift can be also incorporated into this cascade reaction. Copyright
2-Dienylphenacyloxazolones and an intramolecular Diels-Alder approach to the A-B-C ring system of phenanthridone alkaloids
Gaenzler, Faith Corbo,Guo, Chen (Lisa),Zhang, Yun-Wei,Azab, Mohammad E.,Salem, Mounir A.I.,Fan, Dong Ping,Smith, Michael B.
experimental part, p. 8781 - 8785 (2009/12/26)
A general route to the A-B-C ring system of phenanthridone alkaloids is available by acylation of 2-oxa-zolone with a 2-butadienylbenzoic acid derivative, followed by an intramolecular Diels-Alder reaction and hydrolysis.
Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines
Macreadie, Ian G.,Avery, Thomas D.,Robinson, Tony V.,Macreadie, Peter,Barraclough, Miles,Taylor, Dennis K.,Tiekink, Edward R.T.
, p. 1225 - 1232 (2008/09/17)
In an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure-activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and their parent 1,2-dioxines 1 were a
Intramolecular reactions of α-azidocinnamates with 4-substituted 1,3-dienes
Vogel,Delavier,Jones,Doring
, p. 1409 - 1412 (2007/10/02)
The synthesis of new 8,9-benzo-6-aza-bicyclo[3.2.2]nona-3.6.8-trienes 14 by intramolecular reaction of α-azidocinnamates 9 with alkyl- and phenylsubstituted ortho-butadienyl side chains is reported, as is the formation of the new 1-aza-2-carbomethoxy-7,8-benzo-tricyclo[4.30.02,9]nona-4,7-diene 15.
Intramolecular -Cycloaddition Chemistry of Some 1,3-Dienyl-Substituted Cyclopropenes
Padwa, Albert,Kulkarni, Yashwant S.,Terry, Lenny W.
, p. 2478 - 2486 (2007/10/02)
The thermal reaction of several 1,3-dienyl-substituted diphenylcyclopropenes has been studied.Thermolysis of these systems give products derived from an intramolecular -cycloaddition.The reaction involves bond formation between the dienyl ?-bond and
A SYNTHESIS OF THE 6-AZA-BICYCLO(3,2,2)NONANE SKELETON
Vogel, Claus,Delavier, Paul
, p. 1789 - 1792 (2007/10/02)
The construction of the 6-aza-bicyclo(3,2,2)nonane skeleton by a new tandem aziridination/3-aza-Cope rearrangement sequence employing the intramolecular reaction of vinylazides with 1,3-dienes is reported.
