125643-35-8

Upstream product

• 15935-94-1 allylidenetriphenylphosphorane 
• 6630-33-7 ortho-bromobenzaldehyde 
• 71787-51-4 1-(2-bromophenyl)but-3-en-1-ol 
• 1560-54-9 allyltriphenylphosphonium bromide 
• 2622-05-1 allylmagnesium bromide 
• 125643-25-6 1-(2-bromophenyl)-3-buten-2-ol 

Downstream Products

• 1008752-68-8 (+/-)-3-(2-bromophenyl)-3,6-dihydro-1,2-dioxine 
• 72057-19-3 2-(1,3-butadienyl)benzoic acid 
• 124300-67-0 o-butadienyl α-azidocinnamate 
• 124300-57-8 (E)-2-(buta-1,3-dien-1-yl)benzaldehyde 
• 124300-58-9 (Z)-2-(buta-1,3-dien-1-yl)benzaldehyde 
• 66223-53-8 trans-2-bromocinnamaldehyde 

Relevant academic research and scientific papers

Radical-Mediated Heck-Type Alkylation: Stereoconvergent Synthesis of Functionalized Polyenes

The stereospecific synthesis of polyenes is of great synthetic value. Disclosed herein is a new, efficient, stereoconvergent approach for the synthesis of functionalized polyenes via a radical-mediated Heck-type alkylation. The easily accessed Z- and E-mixed alkenes are harnessed as starting material, leading to a unique stereoisomer of polyenes. In addition, the transformation features mild reaction conditions and broad functional group compatibility. A variety of valuable 1,3-dienes and 1,3,5-trienes are afforded in useful yields.

Copper-catalyzed pyrrole synthesis from 3,6-dihydro-1,2-oxazines

Highly-functionalized pyrroles could be effectively synthesized from 3,6-dihydro-1,2-oxazines using a heterogeneous copper on carbon (Cu/C) under neat heating conditions. Furthermore, the in situ formation of 3,6-dihydro-1,2-oxazines via the hetero Diels-Alder reaction between nitroso dienophiles and 1,3-dienes and the following Cu/C-catalyzed pyrrole synthesis also provided the corresponding pyrrole derivatives in a one-pot manner.

A visible-light-mediated oxidative C-N bond formation/aromatization cascade: Photocatalytic preparation of N-arylindoles

Just add light and air: Structurally diverse N-arylindoles can be prepared from readily prepared o-styryl anilines through visible-light photocatalysis. The reaction, which is conducted open to air, is mediated by [Ru(bpz) 3](PF6)2 (bpz=2,2'-bipyrazine) and involves both C-N bond formation and aromatization (see scheme). Using suitably substituted substrates, a 1,2-carbon shift can be also incorporated into this cascade reaction. Copyright

2-Dienylphenacyloxazolones and an intramolecular Diels-Alder approach to the A-B-C ring system of phenanthridone alkaloids

A general route to the A-B-C ring system of phenanthridone alkaloids is available by acylation of 2-oxa-zolone with a 2-butadienylbenzoic acid derivative, followed by an intramolecular Diels-Alder reaction and hydrolysis.

Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines

In an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure-activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and their parent 1,2-dioxines 1 were a

Intramolecular reactions of α-azidocinnamates with 4-substituted 1,3-dienes

The synthesis of new 8,9-benzo-6-aza-bicyclo[3.2.2]nona-3.6.8-trienes 14 by intramolecular reaction of α-azidocinnamates 9 with alkyl- and phenylsubstituted ortho-butadienyl side chains is reported, as is the formation of the new 1-aza-2-carbomethoxy-7,8-benzo-tricyclo[4.30.02,9]nona-4,7-diene 15.

Intramolecular -Cycloaddition Chemistry of Some 1,3-Dienyl-Substituted Cyclopropenes

The thermal reaction of several 1,3-dienyl-substituted diphenylcyclopropenes has been studied.Thermolysis of these systems give products derived from an intramolecular -cycloaddition.The reaction involves bond formation between the dienyl ?-bond and

A SYNTHESIS OF THE 6-AZA-BICYCLO(3,2,2)NONANE SKELETON

The construction of the 6-aza-bicyclo(3,2,2)nonane skeleton by a new tandem aziridination/3-aza-Cope rearrangement sequence employing the intramolecular reaction of vinylazides with 1,3-dienes is reported.