14387-10-1

Basic information

• Product Name: 2-(4-ethylphenyl)acetic acid
• Synonyms: 2-(4-ethylphenyl)acetic acid;(4-ethylphenyl)acetic acid;benzeneacetic acid, 4-ethyl-;4-Ethylbenzeneacetic acid;(4-ethylphenyl)acetic acid(SALTDATA: FREE);2-(4-ethylphenyl)ethanoic acid
• CAS NO: 14387-10-1
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.21
• Mol File: 14387-10-1.mol

Chemical Properties

• Boiling Point: 289.2 °C at 760 mmHg
• Flash Point: 186.4 °C
• Appearance: /
• Density: 1.096 g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: 2-8°C
• PKA: pK1:4.373 (25°C)
• CAS DataBase Reference: 2-(4-ethylphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-ethylphenyl)acetic acid(14387-10-1)
• EPA Substance Registry System: 2-(4-ethylphenyl)acetic acid(14387-10-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 14387-10-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-ethylphenyl)acetic acid is used as a reagent for the synthesis of p-Ethylhydratropic Acid (E918820), which is an impurity found in the production of ibuprofen (I140000). Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) that helps in reducing pain, inflammation, and fever. The synthesis of p-Ethylhydratropic Acid is essential for maintaining the purity and quality of ibuprofen, ensuring its effectiveness and safety for medical use.

InChI:InChI=1/C10H12O2/c1-2-8-3-5-9(6-4-8)7-10(11)12/h3-6H,2,7H2,1H3,(H,11,12)

Upstream product

• 201230-82-2 carbon monoxide 
• 1467-05-6 4-ethylbenzylchloride 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 105-53-3 diethyl malonate 
• 64-18-6 formic acid 
• 110-91-8 morpholine 
• 937-30-4 4-ethylacetophenone 
• 101-97-3 Ethyl 2-phenylethanoate 
• 100-41-4 ethylbenzene 
• 46122-65-0 4-vinylbenzeneacetic acid 
• 7601-90-3 perchloric acid 
• 64-19-7 acetic acid 
• 7664-93-9 sulfuric acid 
• 10408-52-3 (rac)-2-(4-ethylphenyl)-2-hydroxyacetic acid 

Downstream Products

• 1247119-83-0 2-(4-ethylphenyl)-2-methyl-propanoic acid 
• 1256584-73-2 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid 
• 441795-38-6 C₂₅H₂₅BrN₆O₄S 
• 146533-39-3 4,6-dichloro-5-(4-ethyl-phenyl)-pyrimidine 
• 441795-37-5 C₂₁H₂₄N₄O₄S 
• 441797-35-9 C₁₉H₁₉ClN₄O₂S 
• 394207-67-1 C₁₃H₁₆O₄ 
• 792971-31-4 4-(ethyl)-phenyl-ethanoic acid tributyltin ester 
• 143818-88-6 4-[3,3-Diethyl-1-(4-ethyl-benzylcarbamoyl)-4-oxo-azetidin-2-yloxy]-benzoic acid 
• 518976-74-4 1-Ethyl-4-isocyanatomethyl-benzene 
• 609352-24-1 Bromo-(4-ethyl-phenyl)-acetic acid methyl ester 
• 52629-43-3 4-Ethylphenylessigsaeurechlorid 
• 127035-73-8 4-[(E)-2-(4-Ethyl-phenyl)-vinyl]-2,6-dimethyl-phenol 
• 36207-10-0 (4-Ethyl-phenyl)-acetic acid methyl ester 

Relevant articles and documents

Preparation method of alectinib intermediate

The invention discloses a preparation method of 2-(4-ethyl-3-iodine) phenyl-2-methyl propionic acid as an alectinib intermediate. According to the preparation method, the operation danger class and production cost are reduced by optimizing and improving a

A General, Activator-Free Palladium-Catalyzed Synthesis of Arylacetic and Benzoic Acids from Formic Acid

A new catalyst for the carboxylative synthesis of arylacetic and benzoic acids using formic acid (HCOOH) as the CO surrogate was developed. In an improvement over previous work, CO is generated in situ without the need for any additional activators. Key to success was the use of a specific system consisting of palladium acetate and 1,2-bis((tert-butyl(2-pyridinyl)phosphinyl)methyl)benzene. The generality of this method is demonstrated by the synthesis of more than 30 carboxylic acids, including non-steroidal anti-inflammatory drugs (NSAIDs), under mild conditions in good yields.

An efficiently cobalt-catalyzed carbonylative approach to phenylacetic acid derivatives

A highly efficient cobalt-catalyzed carbonylative approach to phenylacetic acid derivatives under one atmosphere pressure is reported. This methodology represents a useful extension of benzimidazole used as ligand in metal catalysis, and the catalytic mechanism has been proved by computer simulation. Notably, this new cobalt precatalyst, which promotes the carbonylation reaction dramatically and has already been used for scale-up experiment of phenylacetic acid derivatives.

Tri-n-butyltin carboxylate derivatives of para-substituted phenyl-ethanoic acids: Synthesis, characterization and X-ray structure determination

The tributyltin esters of 4-(ethyl)-phenyl-ethanoic acid and 4-(isopropyl)-phenyl-ethanoic acid have been prepared as model compounds of the repeating unit of the related stannylated polystyrenic derivatives. Both the products were fully characterized by proton and carbon NMR two-dimensional techniques. FT-IR spectra show in the solid state carboxylated moieties bridging R 3 Sn groups with the metal atom expanding its coordination number, this structure being destroyed in solution. The supramolecular arrangement of the products in the solid state has been investigated by X-ray diffraction, which confirms the pentacoordination at tin in both the products, and indicates a different spatial arrangement of the alkylated aryl groups, as evidenced also by the slightly different thermal properties.

Media controlled photo - Favorskii type rearrangement of α-chloro acetophenones: Synthesis of phenylacetic acids

Photolysis of substituted α-chloro acetophenones has been studied in different solvent systems wherein 1,2-aryl migration is found to be media controlled. Effect of substituents on the migratory aptitude and a direct access to phenylacetic acids, in practical yields, has been described.

Convenient Preparation of Arylacetic Acids by Tetracarbonylcobaltate Anion Catalysed Carbonylation

Tetracarbonylcobaltate catalyst -, has been prepared in 6 hr by pressure carbonylation of cobalt salt in aq alkaline solution containing cyanide catalyst.Carbonylation of arylchloromethyl derivatives in aq methanolic solutions using this catalyst affords arylacetic acids in good yields.

4-Vinylbenzeneacetic acid

A multi-step preparation of 4-vinylbenzeneacetic acid from the readily available 1,4-diethylbenzene is described. The method uses cobalt (II) catalyzed oxidation of 1,4-diethylbenzene to 4-ethylacetophenone followed by oxidative rearrangement of the latte