1256810-92-0

Basic information

• Product Name: Methyl 2-ethynylisonicotinate
• Synonyms: Methyl 2-ethynylisonicotinate
• CAS NO: 1256810-92-0
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Mol File: 1256810-92-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 271.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.15±0.20(Predicted)
• CAS DataBase Reference: Methyl 2-ethynylisonicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-ethynylisonicotinate(1256810-92-0)
• EPA Substance Registry System: Methyl 2-ethynylisonicotinate(1256810-92-0)

Safety Data

• Hazardous Substances Data: 1256810-92-0(Hazardous Substances Data)

Usage

General Description

Methyl 2-ethynylisonicotinate is a chemical compound with the molecular formula C11H9NO2. It is a derivative of isonicotinic acid and contains both a methyl and an ethynyl group. Methyl 2-ethynylisonicotinate is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its reactivity and ability to participate in various chemical reactions. Methyl 2-ethynylisonicotinate has also shown potential biological activity, particularly as an anti-inflammatory and anti-tumor agent, making it of interest in the field of medicinal chemistry. Its versatility and broad range of potential applications make it a valuable compound in the chemical industry.

Upstream product

• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 26156-48-9 methyl 2-bromoisonicotinate 
• 499193-51-0 2-trimethylsilylethynylpyridine-4-carboxylic acid methyl ester 
• 52718-95-3 2-bromonicotinic acid methyl ester 

Downstream Products

• 1393901-69-3 (E)-methyl 2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)vinyl)isonicotinate 
• 1393901-70-6 methyl 2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isonicotinate 
• 1393901-71-7 tert-butyl 4-(4-((4-(2-(4-carbamoylpyridin-2-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393901-72-8 2-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isonicotinamide 
• 1393900-72-5 2-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isonicotinamide 

Relevant articles and documents

Compound, pharmaceutical composition, KDM5C inhibitor and antidepressant

PROBLEM TO BE SOLVED: To provide a compound having a strong KDM5C inhibitory action, and an antidepressant. SOLUTION: The present invention provides a triazole-4-ylpyridine compound represented by the following formula. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

FAK INHIBITORS

A compound of the formula (I): where R1 or R2 is a cycle amine group and R5 is an aromatic group with a carbonyl containing substituent for use as a FAK inhibitor.