1256815-07-2

Usage

Uses

Used in Pharmaceutical Drug Development:
1,4-di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate is utilized as a building block in the synthesis of potential anti-cancer and anti-viral agents. Its distinctive molecular structure allows for the creation of novel therapeutic agents that can target specific biological pathways implicated in various diseases.
Used in Drug Delivery Systems:
1,4-di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate has demonstrated potential as a target for drug delivery systems, where it can be employed to enhance the delivery, bioavailability, and therapeutic outcomes of associated pharmaceuticals. Its chemical properties may facilitate the development of innovative drug carriers that improve the efficacy and safety of drug administration.
Used in Pharmaceutical Formulations:
1,4-di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate also serves as a component in pharmaceutical formulations, contributing to the stability, solubility, and overall performance of the final drug product. Its integration into formulations can lead to improved patient outcomes through enhanced medication efficacy and reduced side effects.

Upstream product

• 1256815-06-1 di-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-piperazine-1,4-dicarboxylate 
• 143540-05-0 2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester 

Downstream Products

• 1246551-25-6 tert-butyl 3-oxo-1,2,5,6,8,8a-hexahydroimidazo[1,5-a]pyrazine-7-carboxylate 
• 1256815-19-6 hexahydro-2-(4-trifluoromethylphenyl)-imidazo[1,5-a]pyrazin-3-one 
• 1002404-84-3 2-benzylhexahydroimidazo[1,5-a]pyrazin-3(2H)-one 
• 1256815-98-1 tert-butyl 2-(4-(trifluoromethyl)phenyl)-hexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-88-9 tert-butyl 2-benzylhexahydro-3-oxoimidazo[1,5-a]pyrazine-7(1H)-carboxylate 
• 1256815-10-7 hexahydro-2-(4-fluorobenzyl)-imidazo[1,5-a]pyrazin-3-one 
• 1256815-11-8 hexahydro-2-(4-methylbenzyl)-imidazo[1,5-a]pyrazin-3-one 
• 1256815-12-9 hexahydro-2-(4-chlorobenzyl)-imidazo[1,5-a]pyrazin-3-one 
• 1256815-13-0 hexahydro-2-(4-methoxybenzyl)-imidazo[1,5-a]pyrazin-3-one 
• 1256815-17-4 hexahydro-2-(3-cyanobenzyl)-imidazo[1,5-a]pyrazin-3-one 
• 1256815-21-0 hexahydro-2-(4-fluorophenyl)-imidazo[1,5-a]pyrazin-3-one 
• 1002404-56-9 hexahydro-2-(4-chlorophenyl)-imidazo[1,5-a]pyrazin-3-one 
• 1256815-22-1 hexahydro-2-(4-cyanophenyl)-imidazo[1,5-a]pyrazin-3-one 
• 1002404-96-7 hexahydro-2-(4-(methylsulfonyl)phenyl)-imidazo[1,5-a]pyrazin-3-one 

Relevant academic research and scientific papers

Convenient synthesis of novel 2-substituted imidazopyrazinone derivatives

Starting from commercially available piperazine-2-carboxylic acid, a series of novel 2-aryl and 2-benzyl substituted imidazopyrazinone were prepared. The intermediates 5a-g were obtained through facile Buchwald-Hartwig coupling reaction, and the effects of catalyst, base, and solvent on the coupling reaction were investigated. The optimal reaction conditions for the coupling reaction were PdCl2(dppf)=NaO-t-Bu=toluene. Taylor & Francis Group, LLC.

Synthesis, biological assay in vitro and molecular docking studies of new imidazopyrazinone derivatives as potential dipeptidyl peptidase IV inhibitors

A series of novel imidazopyrazinone derivatives were synthesized and evaluated with regard to their ability to inhibit dipeptidyl peptidase IV (DPP-IV) in vitro. Of these compounds (2R)-4-oxo-4-[2-(3-carbamoylbenzyl)- hexahydro-3-oxoimidazo [1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan- 2-amine fumaric acid (17h, IC50 = 78 nM) was shown to effectively inhibit the activity of the dipeptidyl peptidase IV enzyme. Molecular docking studies were also performed to illustrate the binding mode of compounds 15c and 17h. Favorable interactions were identified from the binding of inhibitor 15c with DPP-IV. By analogy to the binding mode of compound 15c, it seems that the introduction of a substituted benzyl moiety onto the imidazopyrazinone could remarkably improve the inhibitory activity of compound 17h.