1257265-27-2

Upstream product

• 1012341-50-2 (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid 
• 1257266-74-2 (2R,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pentanoic acid benzyl ester 

Downstream Products

• 1257265-45-4 1-((1S,3R)-1-biphenyl-4-ylmethyl-3-carboxybutylcarbamoyl)-1H-pyrazole-3-carboxylic acid 
• 1257265-46-5 1-((1S,3R)-3-benzyloxycarbonyl-1-biphenyl-4-ylmethylbutylcarbamoyl)-1H-pyrazole-3-carboxylic acid 
• 1257265-29-4 6-((1S,3R)-1-biphenyl-4-ylmethyl-3-carboxybutylcarbamoyl)-4-oxo-4H-pyran-2-carboxylic acid 
• 1257265-57-8 (2R,4S)-4-[(2-benzyl-2H-tetrazole-5-carbonyl)-amino]-5-biphenyl-4-yl-2-methyl-pentanoic acid benzyl ester 
• 1257265-56-7 (2R,4S)-4-[(1-benzyl-1H-tetrazole-5-carbonyl)-amino]-5-biphenyl-4-yl-2-methyl-pentanoic acid benzyl ester 
• 1257266-14-0 (2R,4S)-5-biphenyl-4-yl-4-isocyanato-2-methylpentanoic acid benzyl ester 
• 1257266-76-4 (2R,4S)-5-biphenyl-4-yl-4-(ethoxyoxalyl-amino)-2-methyl-pentanoic acid benzyl ester 
• 1257265-30-7 6-((1S,3R)-3-benzyloxycarbonyl-1-biphenyl-4-ylmethylbutylcarbamoyl)-4-oxo-4H-pyran-2-carboxylic acid 

Relevant academic research and scientific papers

METHOD OF TREATING CONTRAST-INDUCED NEPHROPATHY

The present invention provides the use of a neutral endopeptidase inhibitor, in the manufacture of a medicament for the treatment, amelioration and/or prevention of contrast-induced nephropathy. The invention also relates to the use of a compound of Formula I: wherein R1, R2, R3, R5, X, A3, B1, s and n are defined herein, for the treatment, amelioration and/or prevention of contrast-induced nephropathy. The present invention further provides a combination of pharmacologically active agents for use in the treatment, amelioration and/or prevention of contrast-induced nephropathy.

SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS

The present invention provides a compound of formula (I') or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.