1257266-74-2

Upstream product

• 1012341-50-2 (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 1257265-27-2 (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid benzyl ester hydrochloride 

Relevant academic research and scientific papers

Pharmaceutical composition and compound for treatment on hypertension and heart failure

The invention relates to a pharmaceutical composition and compound for treatment on hypertension and heart failure and their preparation method and use and belongs to the field of pharmaceutical compositions. The pharmaceutical composition comprises an active ingredient N comprising at least one selected from a compound shown in the formula (I), its isomer, prodrug and pharmaceutically acceptable salt and their solvate, and an active ingredient A comprising at least one selected from a compound shown in the formula (II), its isomer, prodrug and pharmaceutically acceptable salt and their solvate. The pharmaceutical composition and compound have good therapeutic effects and a wide application prospect.

SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS

The present invention provides a compound of formula (I') or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.