125741-49-3

Upstream product

• 89-95-2 2-methyl-benzyl alcohol 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 90-02-8 salicylaldehyde 

Downstream Products

• 1049009-41-7 2-(4-nitrobenzoyl)benzaldehyde 

Relevant academic research and scientific papers

Narcissistic self-sorting in self-assembled cages of rare earth metals and rigid ligands

Highly selective, narcissistic self-sorting can be achieved in the formation of self-assembled cages of rare earth metals with multianionic salicylhydrazone ligands. The assembly process is highly sensitive to the length of the ligand and the coordination geometry. Most surprisingly, high-fidelity sorting is possible between ligands of identical coordination angle and geometry, differing only in a single functional group on the ligand core, which is not involved in the coordination. Supramolecular effects allow discrimination between pendant functions as similar as carbonyl or methylene groups in a complex assembly process. Equals among equals: The formation of self-assembled cages of rare earth metals and ligands proceeds through highly selective, narcissistic self-sorting. Pendant functionalities as similar as carbonyl and methylene groups are discriminated in this complex assembly process.

GLUCOSE-SENSITIVE PEPTIDE HORMONES

The present invention relates to a conjugate of the formula P-L-I, wherein P is a peptide hormone effecting the metabolism of carbohydrates in vivo, L is a hydrolysable linker molecule consisting of Lp and Li, and I is a molecule cap

Phthalides by rhodium-catalyzed ketone hydroacylation

(Chemical Equation Presented) Phthalides are biologically relevant five-membered lactones found in herbs, fruits, and vegetables. Herein we communicate the first atom-economical approach to phthalides by using enantioselective ketone hydroacylation. In the presence of Rh[(Duanphos)]X (X = NO3, OTf, OMs), various 2-ketobenzaldehydes undergo intramolecular hydroacylation to produce phthalide products in good yields and 92-98% ee's. Our study highlights the key role counterions play in controlling both reactivity and enantioselectivity. A concise asymmetric total synthesis of the celery extract (S)-(-)-3-n-butylphthalide is also presented.

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the

Synthesis of New Acylhydrazones as Iron-Chelating Compounds

Fourteen acylhydrazides have been condensed with three aromatic o-hydroxy aldehydes (pyridoxal, salicylaldehyde, and 2-hydroxy-1-naphthaldehyde) to give 42 acylhydrazones, of which 38 are new.These compounds complex iron and have shown varying abilities to promote the movement of iron across biological membranes.Their infrared and nuclear magnetic resonance spectra support the structures assigned to them.

Oxomolybdenum(V) Complexes of Some Multidentate N-O Donors

A number of oxomolybdenum(V) complexes of some multidentate N-O donors in the form of Schiff bases have been synthesised and studied.The Schiff bases were obtained by condensing aromatic acid hydrazides with salicyladehyde (ligands designated as L1H2) and with biacetylmonoxyme (ligands designated as L2H2).All these ligands exhibit tridentate fuction in forming the complexes.The ligands L1H2 formed complexes of the type MoO(L1H)Cl2 (Type A), whereas L2H2 yielded complexes of the type Mo2O3(L2H)2Cl2 (Type B).All the type A complexes are mononuclear, while the type B complexes are binuclear with oxygen-bridging between two Mo atoms.The isolated complexes were characterised by elemental analysis, spectroscopic (uv-visible, ir), magnetic and conductance data.