1049009-41-7

Upstream product

• 50366-20-6 N’-(2-hydroxybenzylidene)-4-nitrobenzohydrazide 
• 1285538-69-3 (Z)-N'-(2-hydroxybenzylidene)-4-nitrobenzohydrazide 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 125741-49-3 (E)-N'-(2-hydroxybenzylidene)-4-nitrobenzohydrazide 

Downstream Products

• 1193731-81-5 (S)-3-(4-nitrophenyl)isobenzofuran-1(3H)-one 
• 1285538-73-9 3-(4-nitrophenyl)isobenzofuran-1-carbonitrile 
• 1285538-77-3 dimethyl 1-cyano-4-(4-nitrophenyl)-1,4-dihydro-1,4-epoxynaphthalene-2,3-dicarboxylate 
• 20643-65-6 3-(4-nitrophenyl)isobenzofuran-1(3H)-one 
• 128445-90-9 1,3-Dihydro-1-(4-nitrophenyl)isobenzofuran 
• 1333151-43-1 2-benzyl-3-(4-nitrophenyl)isoindolin-1-one 
• 1333151-40-8 2-methyl-3-(4-nitrophenyl)isoindolin-1-one 

Relevant academic research and scientific papers

Efficient synthesis of functionalized 1,3-dihydroisobenzofurans from salicylaldehydes: Application to the synthesis of escitalopram

An efficient synthesis of substituted 1,3-dihydroisobenzofurans is developed. In this novel route, o-aroylbenzaldehydes, as key intermediates, can be obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. The mild and general st

Synthesis and transformations of novel benzo[C]furans

Some novel 1-cyanoisobenzofurans have been synthesized by a convenient ring closure methodology. The new products easily reacted with electron-deficient olefins and acetylenes to yield Diels-Alder products. Theoretical calculations satisfactorily support the quinonoide character of the new isobenzofuran derivatives. The Japan Institute of Heterocyclic Chemistry.

Phthalides by rhodium-catalyzed ketone hydroacylation

(Chemical Equation Presented) Phthalides are biologically relevant five-membered lactones found in herbs, fruits, and vegetables. Herein we communicate the first atom-economical approach to phthalides by using enantioselective ketone hydroacylation. In the presence of Rh[(Duanphos)]X (X = NO3, OTf, OMs), various 2-ketobenzaldehydes undergo intramolecular hydroacylation to produce phthalide products in good yields and 92-98% ee's. Our study highlights the key role counterions play in controlling both reactivity and enantioselectivity. A concise asymmetric total synthesis of the celery extract (S)-(-)-3-n-butylphthalide is also presented.

A versatile and regiospecific synthesis of functionalized 1,3-diarylisobenzofurans

(Chemical Equation Presented) A convenient, versatile, and regiospecific synthesis of functionalized 1,3-diarylisobenzofurans has been developed. It involves chemoselective addition of arylmagnesium reagents to the aldehyde function of o-aroylbenzaldehydes, themselves readily obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. Various functional groups, including nitro, iodo, or ester functionalities, have thus been positioned with complete regiospecificity on the 1,3-diphenylisobenzofuran backbone.