1257529-92-2

Usage

Uses

Used in Pharmaceutical Industry:
2(3H)-Furanone, 5-[(1S,3S)-1-azido-3-[hydroxyl[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methylpentyl]dihydro-3-(1-methylethyl)-, (3S,5S)can be utilized as a pharmaceutical intermediate or a potential drug candidate due to its unique structure and functional groups. The presence of azide and hydroxyl groups may allow for further chemical modifications and the development of new therapeutic agents.
Used in Chemical Research:
In the field of chemical research, 2(3H)-Furanone, 5-[(1S,3S)-1-azido-3-[hydroxyl[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methylpentyl]dihydro-3-(1-methylethyl)-, (3S,5S)can serve as a starting material for the synthesis of more complex molecules or as a subject of study to understand its reactivity and behavior in various chemical reactions.
Used in Materials Science:
2(3H)-Furanone, 5-[(1S,3S)-1-azido-3-[hydroxyl[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methylpentyl]dihydro-3-(1-methylethyl)-, (3S,5S)-'s unique structure and functional groups may also make it a candidate for the development of new materials with specific properties. For example, it could be used in the creation of advanced polymers, coatings, or other materials with tailored characteristics for various applications.

Upstream product

• 173154-02-4 (2S,4S)-4-azido-2-isopropyl-4-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]butanal 
• 173336-76-0 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene 
• 1219468-81-1 4-iodo-1-methoxy-2-(3-methoxypropoxy)benzene 
• 173153-98-5 (2S,2'S,2S,4S)-2-[2-azido-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyric acid 
• 173154-03-5 (3S,5S)-5-[(1S,3S)-1-azido-3-(hydroxymethyl)-4-methylpentyl]-3-isopropyldihydrofuran-2(3H)-one 
• 173154-01-3 (S)-3-((2S,4S)-4-azido-2-isopropyl-4-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)butanoyl)-4-benzyloxazolidin-2-one 

Downstream Products

• 1315181-73-7 (2S,4S)-4-azido-2-isopropyl-4-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-1-(4-methoxy-3-(3-methoxypropoxy)phenyl)butyl isobutyrate 
• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 1364791-11-6 aliskiren isobutyric acid salt 
• 1364791-13-8 (2S,4S,5S,7S)-4-amino-7-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-5-hydroxy-2-isopropyl-1-(4-methoxy-3-(3-methoxypropoxy)phenyl)-8-methylnonyl isobutyrate 
• 1364791-17-2 (2S,4S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-4-((2S,4S)-4-isopropyl-5-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidin-2-yl)butanamide 
• 1315181-75-9 (2S,4S,5S,7S)-7-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-4-azido-5-hydroxy-2-isopropyl-1-(4-methoxy-3-(3-methoxypropoxy)-phenyl)-8-methylnonyl isobutyrate 
• 1431951-67-5 C₃₂H₄₅NO₇ 
• 1431951-69-7 C₃₂H₄₅NO₅ 
• 900811-48-5 3(S)-isopropyl-5(S)-{1(S)-amino-3(S)-isopropyl-4-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-butyl}-tetrahydrofuran-2-one 
• 866030-35-5 tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate 
• 173338-07-3 tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate 
• 1431951-65-3 C₃₂H₄₅NO₆ 

Relevant academic research and scientific papers

A new synthetic route towards aliskiren intermediates

The synthesis of aliskiren intermediates was accomplished by attaching the 3,4-dialkoxyphenyl unit to precursor C-8 lactone-carboxylic acid derivatives using organometallic reagents. Totally different reactivities of the lactone-carboxylic acid chloride substrate towards organomagnesium and organoboron reagents were observed.

Electronic and steric effects on the intramolecular Schmidt reaction of alkyl azides with secondary benzyl alcohols

The intramolecular Schmidt reaction of simple azido secondary benzyl alcohols has been realized for the first time. Investigation of the electronic and steric effects of the substrates on the product outcome was conducted. Unique intramolecular Schmidt rearrangements were observed with the formation of a cinnamaldehyde derivative and aryl aldehydes, respectively. Using this protocol, an efficient synthesis of dihydrobenzotriazine derivatives was achieved. Moreover, a practical approach to 2-aryl-1-pyrrolines was also accessed.

ALISKIREN INTERMEDIATES AND A PROCESS FOR ANALYZING THE PURITY OF ALISKIREN

The present invention provides aliskiren intermediates and impurities, and processes for preparation thereof. The present invention also provides processes for preparing aliskiren using these intermediates and impurities. These impurities can also be used as reference markers or reference standards in the determination of the purity of aliskiren or intermediates of aliskiren.

METHODS OF TREATING ALZHEIMER'S DISEASE USING ARYL ALKANOIC ACID AMIDES

Disclosed are methods for treating Alzheimer’s disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula 1 (1) wherein the variables R1-R8 and X are defined herein.