125758-77-2Relevant academic research and scientific papers
Novel Thiazolidine-2,4-diones as Potent Euglycemic Agents
Hulin, Bernard,Clark, David A.,Goldstein, Steven W.,McDermott, Ruth E.,Dambek, Paul J.,et al.
, p. 1853 - 1864 (2007/10/02)
A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety.These compounds lower blood glucose levels in the genetically obese and insulin-r
Thiazolidinedione hypoglycemic agents
-
, (2008/06/13)
Hypoglycemic thiazolidine-2,4-dione derivatives of the formula STR1 wherein the dotted line represents a bond or no bond; A and B are each independently CH or N, with the proviso that when A or B is N, the other is CH; X is S, SO, SO2, CH2, CHOH or CO; n is 0 or 1; Y is CHR1 or NR2, with the proviso that when n is 1 and Y is NR2, X is SO2 or CO; Z is CHR3, CH2 CH2, CH=CH, STR2 OCH2, SCH2, SOCH2 or SO2 CH2 ; R, R1, R2 and R3 are each independently hydrogen or methyl; and X1 and X2 are each independently hydrogen, methyl, trifluoromethyl, phenyl, benzyl, hydroxy, methoxy, phenoxy, benzyloxy, bromo, chloro or fluoro; a pharmaceutically-acceptable cationic salt thereof; or a pharmaceutically-acceptable acid addition salt thereof when A or B is N.
