1257629-92-7Relevant articles and documents
NOC chemistry for tuberculosis - Further investigations on the structure-activity relationships of antitubercular isoxazole-3-carboxylic acid ester derivatives
Pieroni, Marco,Lilienkampf, Annamaria,Wang, Yuehong,Wan, Baojie,Cho, Sanghyun,Franzblau, Scott G.,Kozikowski, Alan P.
, p. 1667 - 1672 (2011/12/15)
NOC, NOC! Who's there? We have expanded the body of structure-activity relationships (SAR) regarding the 3-isoxazolecarboxylic acid ethyl esters by the design and synthesis of 5-aryl- and 5-[(N-aryl)amino]methyl analogues. Compounds were active against Mycobacterium tuberculosis (Mtb) at sub-micromolar concentrations and, for selected compounds, no toxicity was observed on Vero cells.