1257633-67-2

Basic information

• Product Name: 1-tert-Butyl-4-diethoxymethyl-1H-[1,2,3]triazole
• Synonyms: 1-tert-Butyl-4-diethoxymethyl-1H-[1,2,3]triazole
• CAS NO: 1257633-67-2
• Molecular Formula: C₁₁H₂₁N₃O₂
• Molecular Weight: 227.30334
• Mol File: 1257633-67-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-tert-Butyl-4-diethoxymethyl-1H-[1,2,3]triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-Butyl-4-diethoxymethyl-1H-[1,2,3]triazole(1257633-67-2)
• EPA Substance Registry System: 1-tert-Butyl-4-diethoxymethyl-1H-[1,2,3]triazole(1257633-67-2)

Safety Data

• Hazardous Substances Data: 1257633-67-2(Hazardous Substances Data)

Usage

General Description

1-tert-Butyl-4-diethoxymethyl-1H-[1,2,3]triazole is a chemical compound with the molecular formula C11H20N4O2. It is a derivative of the triazole compound and is commonly used as a pharmaceutical intermediate. The tert-butyl and diethoxymethyl groups contribute to the compound's stability and solubility. 1-tert-Butyl-4-diethoxymethyl-1H-[1,2,3]triazole has potential applications in the field of medicinal chemistry, particularly in the development of new drugs and pharmaceutical compounds. It is important to handle this chemical with care and follow safety protocols as it may pose health and environmental hazards if not handled properly.

Upstream product

• 10160-87-9 Propiolaldehyde diethyl acetal 
• 622-37-7 Phenyl azide 
• 13686-33-4 t-butyl azide 

Downstream Products

• 129027-65-2 1-(tert-butyl)-1H-1,2,3-triazole-4-carbaldehyde 
• 1334179-85-9 BTTAA 

Relevant articles and documents

Highly-efficient and versatile fluorous-tagged Cu(i)-catalyzed azide-alkyne cycloaddition ligand for preparing bioconjugates

A novel ligand (FBTTBE) for Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) has been developed, which demonstrates not only superior catalytic efficiency but also the ease of removing toxic copper species. FBTTBE has also been successfully applied in the synthesis of radiometal-labeled peptide and antibody without observable transchelation with the non-radioactive Cu(i) catalyst.

CU(I)-CATALYZED AZIDE-ALKYNE CYCLOADDITIONS (CUAAC) LIGANDS AND METHODS FOR CARRYING OUT CU(I)-CATALYZED AZIDE-ALKYNE CYCLOADDITION REACTIONS

A Cu(I)-Catalyzed Azide-Alkyne Cycloadditions (CuAAC) ligand comprising: a catalytic core; a fluorous tag; and a linker binding the fluorous tag to the catalytic core. A method for carrying out a Cu(I)-Catalyzed Azide-Alkyne Cycloaddition reaction, comprising: combining in a solution an alkyne-tagged component, an azide-tagged component and a Cu(I)-Catalyzed Azide-Alkyne Cycloadditions (CuAAC) ligand comprising: a catalytic core; a fluorous tag; and a linker binding the fluorous tag to the catalytic core; filtering the solution through a solid phase extraction filter to remove Cu(I)-ligand catalyst and/or excess ligand.

Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood

Tpl2 (cot/MAP3K8) is an upstream kinase of MEK in the ERK pathway. It plays an important role in Tumor Necrosis Factor-α (TNF-α) production and signaling. We have discovered that 8-halo-4-(3-chloro-4-fluoro-phenylamino)-6-[(1H-[1,2,3]triazol-4-ylmethyl)-a