1257874-86-4

Basic information

• Product Name: C₃₈H₅₇N₇O₇
• Synonyms: C₃₈H₅₇N₇O₇
• CAS NO: 1257874-86-4
• Molecular Weight: 723.913
• Mol File: 1257874-86-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₈H₅₇N₇O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₈H₅₇N₇O₇(1257874-86-4)
• EPA Substance Registry System: C₃₈H₅₇N₇O₇(1257874-86-4)

Safety Data

• Hazardous Substances Data: 1257874-86-4(Hazardous Substances Data)

Upstream product

• 109183-71-3 N-(tert-butoxycarbonyl)-L-cyclohexylglycine 
• 75658-83-2 cis-1,2-bis(hydroxymethyl)cyclopentane 
• 98516-07-5 (1S,2R)-2-(hydroxymethyl)cyclopentylmethyl acetate 
• 1205676-33-0 (3aS,6aR)-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrole 

Downstream Products

• 402957-28-2 (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide 
• 402959-36-8 (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-[(2-pyrazinylcarbonyl)amino] acetyl]amino]-3,3-dimethylbutanoyl]-N-[(1S)-1-[(cyclopropylamino)(hydroxy)acetyl]butyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide 

Relevant articles and documents

Ugi and Passerini reactions of biocatalytically derived chiral aldehydes: Application to the synthesis of bicyclic pyrrolidines and of antiviral agent telaprevir

Lipase mediated desymmetrization of a meso-diol (1,2-cyclopentanedimethanol) allows the synthesis of both enantiomers of some chiral aldehydes, whose behavior in Passerini and Ugi reactions has been explored. Exploiting these two complementary multicomponent reactions and coupling them with a subsequent cyclization process, we observed that 6 out of all 8 possible stereoisomers of peptidomimetic pyrrolidines can be obtained in good yields. The potential of these protocols has been proved by the development of a new efficient synthesis of antiviral drug telaprevir.