1258306-19-2Relevant academic research and scientific papers
Synthesis of β-keto esters in-flow and rapid access to substituted pyrimidines
Bartrum, Hannah E.,Blakemore, David C.,Moody, Christopher J.,Hayes, Christopher J.
, p. 8674 - 8676 (2011/03/19)
We have developed an in-flow process for the synthesis of β-keto esters via the BF3·OEt2-catalyzed formal C-H insertion of ethyl diazoacetate into aldehydes. The β-keto esters were then condensed with a range of amidines to give a variety of 2,6-substituted pyrimidin-4-ols.
