1258440-83-3

Upstream product

• 685103-95-1 2-hydroxy-5-iodobenzonitrile 
• 75-30-9 2-iodo-propane 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 515832-52-7 5-bromo-2-[(1-methylethyl)oxy]benzonitrile 
• 611-20-1 salicylonitrile 

Downstream Products

• 1258440-84-4 2-[(1-methylethyl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 1258440-85-5 2-[(1-methylethyl)oxy]-5-(1,3-thiazol-2-yl)benzonitrile 
• 1258440-86-6 5-(5-bromo-1,3-thiazol-2-yl)-2-[(1-methylethyl)oxy]benzonitrile 
• 1258440-87-7 5-[5-(5-ethyl-3,4-dihydro-isoquinolin-6-yl)-thiazol-2-yl]-2-isopropoxybenzonitrile 
• 1258440-88-8 5-[5-(5-ethyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-thiazol-2-yl]-2-isopropoxybenzonitrile 
• 1258440-10-6 2-[(1-methylethyl)oxy]-5-[5-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3,4-thiadiazol-2-yl]benzonitrile mono-trifluoroacetate 
• 1258440-14-0 3-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]propanoic acid sodium salt 
• 1258440-16-2 4-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]butanoic acid sodium salt 
• 1258440-17-3 2-[(1-methylethyl)oxy]-5-[5-(1,2,3,4-tetrahydro-6-isoquinolinyl)-1,3,4-thiadiazol-2-yl]benzonitrile 
• 1258440-18-4 2-[(1-methylethyl)oxy]-5-[5-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,3,4-thiadiazol-2-yl]benzonitrile monohydrochloride 
• 1258440-68-4 1,1-dimethylethyl 7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 
• 1258440-72-0 tert-butyl 6-(5-(3-cyano-4-isopropoxyphenyl)-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1258440-13-9 2-[(1-methylethyl)oxy]-5-[5-(5-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)-1,3,4-thiadiazol-2-yl]benzonitrile monohydrochloride 
• 1258440-73-1 ethyl 3-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-5-methyl-3,4-dihydro-2(1H)-isoquinolinyl]propanoate 

Relevant academic research and scientific papers

Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors

A diverse library of 1-phenyl-pyrazole-4-carboxylic acid derivatives were synthesized and evaluated for their inhibitory potency against xanthine oxidoreductase (XOR) in vitro and vivo, and the structure-activity relationship (SAR) analyses were also pres

S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING

The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Thiazole or thiadizaloe derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated