1258512-95-6Relevant articles and documents
Expanding the scope of oligo-pyrrolinone-pyrrolidines as protein-protein interface mimics
Raghuraman, Arjun,Xin, Dongyue,Perez, Lisa M.,Burgess, Kevin
, p. 4823 - 4833 (2013/07/05)
Oligo-pyrrolinone-pyrrolidines (generic structure 1) have the potential to interfere with protein-protein interactions (PPIs), but to reduce this to practice it is necessary to be able to synthesize these structures with a variety of different side chains
Tetramic acids and derivatives by telluride-triggered dieckmann cyclizations
Dittmer, Donald C.,Avilov, Dmitry V.,Kandula, Venkata Subbarao,Purzycki, Matthew T.,Martens, Zachary J.,Hohn, Elliot B.,Bacler, Matthew W.
experimental part, p. 61 - 83 (2010/09/10)
Treatment of α-bromoacyl amides of esters of N-protected α-amino acids with lithium telluride yields an amide enolate which cyclizes to unstable tetramic acids (2, 4-pyrrolidinediones) which can be converted to stable derivatives (e.g. enol esters, silyl enol ethers, enol tosylates). Reaction conditions are modified to reduce unwanted side reactions: protonation of the enolate, selfcatalyzed intermolecular aldol rections of the tetramic acids, and potential racemization at the α-carbon atom of the amino acid.