1258525-98-2Relevant academic research and scientific papers
Steroidal C-21 heteroaryl thioethers. Part 3: Pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids)
Biju, Purakkattle,Wang, Hongwu,Anthes, John,McCormick, Kevin,Aslanian, Robert,Berlin, Michael,Bitar, Rema,Lim, Yeon-Hee,Lee, Yoon Joo,Prelusky, Daniel,McLeod, Robbie,Jia, Yanlin,Fernandez, Xiomora,Lieber, Gissela,Jimenez, Johanna,Eckel, Steve,House, Aileen,Chapman, Richard,Phillips, Jonathan
, p. 3291 - 3295 (2012/06/18)
The introduction of A ring pyrazole modification to the hydrocortisone C-21 heteroaryl thioethers generated compounds with excellent transrepression potency (IL-8 inhibition) compared to their hydrocortisone analogs. However, the transcriptional transacti
NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS, COMPOSITIONS AND USES THEREOF
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Page/Page column 110, (2010/12/31)
The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: Formula (I) wherein L, R1, R2, R
