1258538-82-7Relevant academic research and scientific papers
Synthesis of 4-aryl-1,7-naphthyridine-2(1H)-thiones by the electrocyclic reaction of 4-(1-arylalk-1-enyl)-3-isothiocyanatopyridines Generated in situ from the corresponding Isocyanides
Kobayashi, Kazuhiro,Kozuki, Taketoshi,Suzuki, Teruhiko
experimental part, p. 556 - 563 (2012/05/20)
A convenient synthis for 4-substituted and 3,4-disubstituted 1,7-naphthyridine-2(1H)-thiones 7 has been developed. The method is based on the electrocyclic reaction of 4-(1-arylalk-1-enyl)-3-isothiocyanatopyridines 6, generated in situ by the treatment of the respective isocyanides 5 with S 8 in the presence of a catalytic amount of selenium. The isocyanides 5 can be easily prepared from commercially available pyridin-3-amine by conventional organic reactions.
Synthesis of 2,4,8-trisubstituted 1,7-naphthyridines by the reaction of 4-(1-aryl-2-methoxyethenyl)-3-isocyanopyridines with excess organolithiums
Kobayashi, Kazuhiro,Kozuki, Taketoshi,Fukamachi, Shuhei,Konishi, Hisatoshi
experimental part, p. 2086 - 2093 (2010/12/25)
A convenient method for the synthesis of 2,4,8-trisubstituted 1,7-naphthyridines 6 by the reaction of (E)-4-(1-aryl-2-methoxyethenyl)-3- isocyanopyridines 4, which could be easily prepared from commercially available 3-aminopyridine via aroylation of lithium (4-lithiopyridin-3-yl)pivalamide with N-methoxy-N-methylbenzamides, with excess organolithiums has been developed.
