1258539-07-9

Upstream product

• 70298-88-3 N-(pyridin-3-yl)pivalamide 
• 122334-36-5 N-methoxy-N,4-dimethylbenzamide 

Downstream Products

• 1258538-82-7 (3-aminopyridin-4-yl)(4-methylphenyl)methanone 
• 1373775-08-6 4-(4-methylphenyl)-1,7-naphthyridine-2(1H)-thione 
• 1373775-00-8 3-isocyano-4-[1-(4-methylphenyl)ethenyl]pyridine 
• 1373774-92-5 N-{4-[1-(4-methylphenyl)ethenyl]pyridin-3-yl}formamide 
• 1373774-84-5 4-[1-(4-methylphenyl)ethenyl]pyridin-3-amine 
• 1373774-76-5 1-(3-aminopyridin-4-yl)-1-(4-methylphenyl)ethanol 

Relevant academic research and scientific papers

Synthesis of 4-aryl-1,7-naphthyridine-2(1H)-thiones by the electrocyclic reaction of 4-(1-arylalk-1-enyl)-3-isothiocyanatopyridines Generated in situ from the corresponding Isocyanides

A convenient synthis for 4-substituted and 3,4-disubstituted 1,7-naphthyridine-2(1H)-thiones 7 has been developed. The method is based on the electrocyclic reaction of 4-(1-arylalk-1-enyl)-3-isothiocyanatopyridines 6, generated in situ by the treatment of the respective isocyanides 5 with S 8 in the presence of a catalytic amount of selenium. The isocyanides 5 can be easily prepared from commercially available pyridin-3-amine by conventional organic reactions.

Synthesis of 2,4,8-trisubstituted 1,7-naphthyridines by the reaction of 4-(1-aryl-2-methoxyethenyl)-3-isocyanopyridines with excess organolithiums

A convenient method for the synthesis of 2,4,8-trisubstituted 1,7-naphthyridines 6 by the reaction of (E)-4-(1-aryl-2-methoxyethenyl)-3- isocyanopyridines 4, which could be easily prepared from commercially available 3-aminopyridine via aroylation of lithium (4-lithiopyridin-3-yl)pivalamide with N-methoxy-N-methylbenzamides, with excess organolithiums has been developed.