125867-25-6

Basic information

• Product Name: 2-(2,2-DIMETHYL-PROPIONYLAMINO)-NICOTINIC ACID
• Synonyms: 2-(Pivalamino)nicotinic acid;2-(2,2,2-TRIMETHYLACETAMIDO)NICOTINIC ACID;2-pivalamidonicotinic acid;RARECHEM AL BE 1233;2-(PIVALOYLAMINO)NICOTINIC ACID;2-[(2,2-DIMETHYLPROPANOYL)AMINO]NICOTINIC ACID;2-(2,2-DIMETHYL-PROPIONYLAMINO)-NICOTINIC ACID
• CAS NO: 125867-25-6
• Molecular Formula: C11H14N2O3
• Molecular Weight: 222.24
• Mol File: 125867-25-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 235.2-236.7°C
• Boiling Point: 449.6°Cat760mmHg
• Flash Point: 225.7°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 7.18E-09mmHg at 25°C
• CAS DataBase Reference: 2-(2,2-DIMETHYL-PROPIONYLAMINO)-NICOTINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,2-DIMETHYL-PROPIONYLAMINO)-NICOTINIC ACID(125867-25-6)
• EPA Substance Registry System: 2-(2,2-DIMETHYL-PROPIONYLAMINO)-NICOTINIC ACID(125867-25-6)

Safety Data

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• HazardClass: IRRITANT
• Hazardous Substances Data: 125867-25-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 26, p. 105, 1989 DOI: 10.1002/jhet.5570260119

InChI:InChI=1/C11H14N2O3/c1-11(2,3)10(16)13-8-7(9(14)15)5-4-6-12-8/h4-6H,1-3H3,(H,14,15)(H,12,13,16)/p-1

Upstream product

• 124-38-9 carbon dioxide 
• 86847-59-8 2-(pivaloylamino)pyridine 

Relevant articles and documents

Synthesis of ortho-substituted aminopyridines. Metalation of pivaloylamino derivatives

The three isomeric pivaloylaminopyridines were lithiated in more than 80% yields. Aminopyridine derivatives were treated by 2.5-3 equivalents of the complex BuLi-TMEDA at -10° in diethyl ether. Reaction of the lithiated species with various electrophiles afforded a number of ortho-substituted pivaloylaminopyridines in good yields. Secondary pyridine alcohols were oxidized to the corresponding aminopyridyl ketones. Pyridopyrimidines, benzonaphthyridines as well as an analogue of the natural antitumor alkaloid ellipticine has been synthesized showing the versatility of the method.