1258758-75-6Relevant academic research and scientific papers
A metal-free, three-component manifold for the C2-functionalization of 1-substituted imidazoles operating on water
Cruz-Acosta, Fabio,De Armas, Pedro,García-Tellado, Fernando
, p. 2421 - 2424 (2010)
A metal-free, three-component process for the C2-functionalization of N-alkylated imidazoles is reported The multicomponent manifold operates under on water conditions through the formation of a water-stable (permanent) nucleophilic imidazole carbene (imidazolium ylide). Whereas the incorporated vinyl ether functionality is a convenient handle for further chemical manipulation of the functionalized heterocycle (complexity generation), the use of water as the reaction media gives it a bonus of added benefits in terms of safety, bench-friendly processing and environmental care. Georg Thieme Verlag Stuttgart New York.
