1258786-30-9Relevant academic research and scientific papers
Ultrasonic-assisted green synthetic method for 2-sulfonyl pyridine derivatives
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Paragraph 0105-0111, (2019/01/16)
The invention discloses an ultrasonic-assisted green synthetic method for 2-sulfonyl pyridine derivatives. The 2-sulfonyl pyridine derivatives are synthesized from 2-halogenated pyridine compounds, sulfonyl chloride compounds and sulfite by one-pot reaction in an aqueous solution under the ultrasonic-assisted action. The raw materials are easily available, the reaction conditions are simple, mild,green and energy-saving, the reaction selectivity and yield are high, and compatibility of substrate functional groups is excellent; particularly, the 2-sulfonyl pyridine derivatives can be obtainedby filtering and direct separation, production cost is reduced, the problem of environmental pollution of the traditional method is solved, and the method has higher application value.
Convenient and Inexpensive Route to Sulfonylated Pyridines via S N Ar Reaction of Electron-Rich Pyridines by Iron Catalysis
Chen, Fei,Chacón-Huete, Franklin,El-Husseini, Hassan,Forgione, Pat
, p. 1914 - 1920 (2018/02/28)
Sulfonylated pyridines were synthesized in moderate to excellent yields, with a wide scope of substituted pyridines and sulfinate salts as starting materials, by an iron-catalyzed S N Ar reaction. This new methodology exhibits advantages for the synthesis of these useful substrates, such as the use of a readily available, inexpensive catalyst, prevention of the disproportionation of the sulfinate salts, and, more importantly, providing access to electron-rich pyridine substrates.
Modifiable sulfur tethers as directing groups for aromatic C-H acetoxylation reactions
Richter, Heinrich,Beckendorf, Stephan,Mancheno, Olga Garcia
supporting information; experimental part, p. 295 - 302 (2011/04/16)
A designed new class of modifiable sulfur tethers for aromatic C-H bond functionalizations is presented. As a model, the palladium-catalyzed directed acetoxylation reaction was studied. The more challenging sulfoxide tethers were the most effective in this transformation, showing a broad functionality tolerance, high S oxido-redox stability and no catalyst poisoning. Preliminary mechanistic studies indicate that the higher reactivity and selectivity shown by the sulfoxide tethers vs. the corresponding sulfones can be attributed to an extra coordination of the sulfoxide S atom to the catalyst. The utility of the presented methodology to generate structurally interesting aromatic derivatives by a subsequent modification of the S-tether is also exemplified.
A practical, one-pot synthesis of sulfonylated pyridines
Maloney, Kevin M.,Kuethe, Jeffrey T.,Linn, Kathleen
supporting information; experimental part, p. 102 - 105 (2011/03/19)
A concise and efficient one-pot synthesis of functionalized sulfonylated pyridines via an SNAr reaction of readily available pyridines and sodium sulfinate salts in the presence of tetrabutylammonium chloride is presented.
