1258795-43-5

Basic information

• Product Name: (1-(4-(thiophen-2-yl)thiazol-2-yl)-1H-1,2,3-triazol-4-yl)methyl (E)-cinnamate
• Synonyms: (1-(4-(thiophen-2-yl)thiazol-2-yl)-1H-1,2,3-triazol-4-yl)methyl (E)-cinnamate
• CAS NO: 1258795-43-5
• Molecular Weight: 394.478
• Mol File: 1258795-43-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1-(4-(thiophen-2-yl)thiazol-2-yl)-1H-1,2,3-triazol-4-yl)methyl (E)-cinnamate(CAS DataBase Reference)
• NIST Chemistry Reference: (1-(4-(thiophen-2-yl)thiazol-2-yl)-1H-1,2,3-triazol-4-yl)methyl (E)-cinnamate(1258795-43-5)
• EPA Substance Registry System: (1-(4-(thiophen-2-yl)thiazol-2-yl)-1H-1,2,3-triazol-4-yl)methyl (E)-cinnamate(1258795-43-5)

Safety Data

• Hazardous Substances Data: 1258795-43-5(Hazardous Substances Data)

Upstream product

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Relevant articles and documents

One-pot tandem copper-catalyzed library synthesis of 1-thiazolyl-1,2,3- triazoles as anticancer agents

One-pot multicomponent synthesis to assemble compounds has been an efficient method for constructing a compound library. We have developed one-pot tandem copper-catalyzed azidation and CuAAC reactions that afford 1-thiazolyl-1,2,3-triazoles with anticancer activity. By utilizing this one-pot synthetic strategy, we constructed a library of 1-thiazolyl-1,2,3-triazoles in search of the potent lead compound. Furthermore, 1-thiazolyl-1,2,3-triazoles were evaluated for anticancer activity against the multidrug-resistant cancer cells MES-SA/Dx5. Most of the 1-thiazolyl-1,2,3-triazoles revealed cytotoxic effect against cancer cells at micromolar to low micromolar range. Testing some of the most potent compounds (5{4,2-4} and 5{5,1-3}) against the normal cell line Vero showed no significant toxicity (except 5{4,2}) to normal cells. This result indicates that compounds 5{4,3-4} and 5{5,1-3} possessed good potency and selectivity to cancer cells over normal cells.