1258944-85-2Relevant academic research and scientific papers
Boron-Catalyzed Silylative Reduction of Nitriles in Accessing Primary Amines and Imines
Gandhamsetty, Narasimhulu,Jeong, Jinseong,Park, Juhyeon,Park, Sehoon,Chang, Sukbok
, p. 7281 - 7287 (2015)
Silylative reduction of nitriles was studied under transition metal-free conditions by using B(C6F5)3 as a catalyst with hydrosilanes as a reductant. Alkyl and (hetero)aryl nitriles were efficiently converted to primary amines or imines under mild conditions. The choice of silanes was found to determine the selectivity: while a full reduction of nitriles was highly facile, the use of sterically bulky silanes allowed for the partial reduction leading to N-silylimines.
Chemoselective catalytic hydrosilylation of nitriles
Gutsulyak, Dmitry V.,Nikonov, Georgii I.
supporting information; experimental part, p. 7553 - 7556 (2010/12/19)
Well-behaved: The ruthenium complex [Cp(iPr3P)Ru(NCCH 3)2]+ (Cp=cyclopentadienyl) catalyzes monohydrosilylation of nitriles (see scheme) with unprecedented tolerance of most common functional groups. The catalyst is easily synthesized starting from commercially available compounds, is air-stable, recyclable, and works under solvent-free conditions.
