1259294-08-0

Basic information

• Product Name: 7-(4-methoxyphenyl)-2H-chromen-2-one
• Synonyms: 7-(4-methoxyphenyl)-2H-chromen-2-one
• CAS NO: 1259294-08-0
• Molecular Weight: 252.269
• Mol File: 1259294-08-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-(4-methoxyphenyl)-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-methoxyphenyl)-2H-chromen-2-one(1259294-08-0)
• EPA Substance Registry System: 7-(4-methoxyphenyl)-2H-chromen-2-one(1259294-08-0)

Safety Data

• Hazardous Substances Data: 1259294-08-0(Hazardous Substances Data)

Upstream product

• 141-32-2 acrylic acid n-butyl ester 
• 107203-08-7 3-(4-methoxyphenyl)cyclohexanone 
• 5720-07-0 4-methoxyphenylboronic acid 
• 108530-10-5 2-oxo-2H-benzopyran-7-yl trifluoromethanesulfonate 
• 531-59-9 7-methoxycoumarin 
• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 

Relevant articles and documents

Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial–Mesenchymal Transition and Migration in A549 Cells

A series of coumarin derivatives and isosteres were synthesized from the reaction of triflic intermediates with phenylboronic acids, terminal alkynes, and organozinc compounds through palladium-catalyzed cross-coupling reactions. The in vitro cytotoxic ef

Synthesis and biological evaluation of (6- and 7-Phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is an enzyme that catalyzes NADPH-dependent reduction of the weak estrogen, estrone, into the most potent estrogen, estradiol, which exerts proliferative effects via the estrogen receptors. Overexpression of 17β-HSD1 in estrogen-responsive tissues is related to the development of hormone-dependent diseases, such as breast cancer and endometriosis; thus, 17β-HSD1 represents an attractive target for the development of new therapies. We have discovered that simple coumarines 1 and 2 significantly inhibit 17β-HSD1 in a recombinant enzyme assay, with high selectivity against 17β-HSD2. We postulated that the introduction of various p-substituted phenyl moieties to position 6 or 7 of the coumarin core using the Suzuki-Miyaura cross-coupling reaction would provide mimetics of steroidal structures with improved inhibition of 17β-HSD1. The best inhibitor in the series proved to be 6a, with an IC50 of 270 nM, and with exceptional selectivity for 17β-HSD1 over 17β-HSD2 and against the α and β estrogen receptors.