1259446-90-6Relevant academic research and scientific papers
Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors
Ghosh, Arun K.,Xu, Chun-Xiao,Rao, Kalapala Venkateswara,Baldridge, Abigail,Agniswamy, Johnson,Wang, Yuan-Fang,Weber, Irene T.,Aoki, Manabu,Miguel, Salcedo Gomez Pedro,Amano, Masayuki,Mitsuya, Hiroaki
, p. 1850 - 1854 (2010)
A healthier HAART: We report the design, synthesis, biological evaluation, and X-ray crystallographic analysis of a new class of HIV-1 protease inhibitors. Compound 4 proved to be an extremely potent inhibitor toward various multidrug-resistant HIV-1 variants, representing a near 10-fold improvement over darunavir (DRV). Compound 4 also blocked protease dimerization with at least 10-fold greater potency than DRV.
