125962-60-9

Usage

Category

Spiro compound
A type of organic compound containing a carbon atom linked to two non-adjacent carbon atoms.

Structural components

1,4-dioxane moiety and 4-bromophenyl substituent
The spiro ring system consists of a 1,4-dioxane (a six-membered ring with two oxygen atoms) and a 4-bromophenyl group (a phenyl group with a bromine atom attached to the fourth carbon).

Applications

Organic synthesis and pharmaceutical research
Used as a building block for the preparation of various chemical compounds.

Potential applications

Material science and agrochemistry
Due to its chemical structure and properties, it may have uses in these fields.

Safety precautions

Proper handling and safety measures required
As with any chemical compound, it is essential to follow safety protocols to ensure the safety of researchers and the environment.

Upstream product

• 125962-59-6 4-Hydroxy-4-(p-bromophenyl)cyclohexanone ethylene ketal 
• 107-21-1 ethylene glycol 
• 680596-79-6 4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane 
• 589-87-7 1,4-bromoiodobenzene 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 106-37-6 1.4-dibromobenzene 

Downstream Products

• 1078729-38-0 4-(4'-ethoxy-2',3'-difluoro-(1,1'-biphenyl)-4-yl)cyclohexanone 
• 1078729-37-9 8-(4'-ethoxy-2',3'-difluoro-(1,1'-biphenyl)-4-yl)-1,4-dioxaspiro(4.5)decane 

Relevant academic research and scientific papers

Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins

Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein we report a novel desymmetric isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodology is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatizations.

SUBSTITUTED PYRAZOLE COMPOUNDS AS TOLL RECEPTOR INHIBITORS

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

NOVEL 5 or 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.

LIQUID CRYSTAL COMPOUND HAVING HALOGENATED ALKYL, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT

PROBLEM TO BE SOLVED: To provide a liquid crystal compound satisfying at least one of demands for physical properties such as high stability to heat or light, high clearing point (or high maximum temperature), low minimum temperature of a liquid crystal phase, small viscosity, suitable optical anisotropy, large dielectric anisotropy, suitable elastic modulus, and excellent compatibility with other liquid crystal compounds, a liquid crystal composition comprising the above compound, and a liquid crystal display element including the composition. SOLUTION: The compound is represented by formula (1). In formula (1), R1X represents an alkyl substituted with a halogen; ring A1, ring A2, ring A3, ring A4 and ring A5 represent a 1,4-phenylene or the like; Z1, Z2, Z3 and Z4 represent a single bond, -COO-, or the like; X1 represents fluorine, -CF3, or the like; L1 and L2 represent fluorine or the like; and a, b, c and d represent 0 or 1. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

LIQUID CRYSTAL COMPOUNDS AND METHOD FOR PREPARING THE SAME

The present invention relates to a liquid crystal compound for liquid crystal display. More particularly, the present invention provides a vinylcyclohexylbenzene, its derivatives and the preparation method thereof where the present invention produces only

Cyclic imino derivatives and pharmaceutical compositions containing them

The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.

A Search for Photoresolvable Mesogens: Synthesis and Properties of a Series of Liquid Crystalline, Axially Chiral 1-Benzylidene-4-phenyl>cyclohexanes

A series of axially chiral 1-benzylidene-4-ethynyl>phenyl>cyclohexanes was prepared in racemic form and as optically active mixtures by application of the Hanessian olefination reaction.These compounds have two spectrally overlapping g