125991-64-2

Upstream product

• 125991-63-1 diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate 
• 105580-41-4 4-acetylbenzoic acid tert-butyl ester 
• 130351-30-3 ethyl 5-<4-(tert-butoxycarbonyl)phenyl>-5-hydroxy-2-hexenoate 
• 125991-47-1 ethyl 5-<4-(tert-butoxycarbonyl)phenyl>-2-(dicyanomethyl)hexanoate 
• 130377-72-9 tert-butyl 4-<3-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate 
• 1118-89-4 diethyl-L-glutamate hydrochloride 

Relevant academic research and scientific papers

Pyrrolopyrimidine derivatives, their production and use

A compound of the formula STR1 wherein the ring A is a pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR1 and --COOR2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.

Novel Pyrrolopyrimidine Antifolates: Synthesis and Antitumor Activities

New antifolates, characterized by a 6-5 fused ring system, a pyrrolopyrimidine ring, and a trimethylene bridge at position 5 (12a,b and 13a,b) were designed and efficiently synthesized.The synthetic method included (1) construction of the key inter