1260084-77-2Relevant academic research and scientific papers
A facile enantioselective synthesis of (S)-N-(5-chlorothiophene-2-sulfonyl) -β,β-diethylalaninol via proline-catalyzed asymmetric α-aminooxylation and α-amination of aldehyde
Rawat, Varun,Chouthaiwale, Pandurang V.,Chavan, Vilas B.,Suryavanshi, Gurunath,Sudalai, Arumugam
, p. 6565 - 6567 (2010)
A high-yielding enantioselective synthesis of the bioactive (S)-N-(5-chlorothiophene-2-sulfonyl)-β,βdiethylalaninol (1), a Notch-1-sparing γ-secretase inhibitor metabolite (with EC50 = 28 nM) effective in reduction of Aβ production in vivo, has
Process for the Preparation of Beta-Amino Alcohol
-
, (2013/02/28)
A high-yielding enantioselective synthesis of the bioactive (S)—N-(5-chlorothiophene-2-sulfonyl)- β,β-diethylalaniol (7.b.2), a Notch-1-sparing γ-secretase inhibitor metabolite (with EC50=28 nM) effective in reduction of Aβ production in vivo,
