1260230-34-9

Basic information

• Product Name: 2-(4-methyl-1,2,3-thiadiazole-5-carbonyl)-N-phenylhydrazinecarbothioamide
• Synonyms: 2-(4-methyl-1,2,3-thiadiazole-5-carbonyl)-N-phenylhydrazinecarbothioamide
• CAS NO: 1260230-34-9
• Molecular Weight: 293.373
• Mol File: 1260230-34-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-methyl-1,2,3-thiadiazole-5-carbonyl)-N-phenylhydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methyl-1,2,3-thiadiazole-5-carbonyl)-N-phenylhydrazinecarbothioamide(1260230-34-9)
• EPA Substance Registry System: 2-(4-methyl-1,2,3-thiadiazole-5-carbonyl)-N-phenylhydrazinecarbothioamide(1260230-34-9)

Safety Data

• Hazardous Substances Data: 1260230-34-9(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 75423-15-3 4-methyl-4,5-dihydro-1,2,3-thiadiazole-5-carbohydrazide 

Downstream Products

• 1260230-40-7 4-phenyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)-s-triazole-3-thione 
• 1260230-45-2 2-(phenylamino)-5-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3,4-thiadiazole 
• 1569753-02-1 5-(5-((3,4-dichlorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1569752-99-3 5-(5-(((2-chlorothiazol-5-yl)methyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1569752-95-9 5-(5-((4-(tert-butyl)benzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1569752-92-6 2-((5-(4-methyl-1,2,3-thiadiazol-5-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetonitrile 
• 1417895-51-2 5-(5-((3-chlorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1417895-61-4 4-methyl-5-(4-phenyl-5-(propylthio)-4H-1,2,4-triazol-3-yl)-1,2,3-thiadiazole 
• 1417895-59-0 4-methyl-5-(5-((4-ethylbenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,2,3-thiadiazole 
• 1417895-58-9 4-methyl-5-(5-((4-methylbenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,2,3-thiadiazole 
• 1417895-55-6 5-(5-((2-fluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1417895-56-7 5-(5-((3-fluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1417895-53-4 5-(5-((3-chlorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1417895-63-6 (5-(5-benzylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 

Relevant articles and documents

Microwave assisted synthesis, antifungal activity and DFT theoretical study of some novel,1,2,4-triazole derivatives containing the 1,2,3-thiadiazole moiety

In order to investigate the biological activity of 1,2,4-triazole compounds, seventeen novel 1,2,4-triazole derivatives containing 1,2,3-thiadiazole moieties were synthesized by multi-step reactions under microwave assisted conditions. The structures were characterized by 1H-NMR, 13C-NMR, MS and elemental analyses. The target compounds were evaluated for their in vivo fungicidal activities against Corynespora cassiicola, Pseudomonas syringae pv. Lachrymans, and Pseudoperonospora cubensis, and the results indicated that some of the title compounds displayed good fungicidal activities. Theoretical calculations on the title compounds were carried out at the B3LYP/6-31G (d,p). level. The full geometry optimization was carried out using the 6-31G(d,p) basis set, and the frontier orbital energy, atomic net charges were discussed, and the structure-activity relationships were also studied.

Study of direction of cyclization of 1-azolil-4-aryl/alkyl- thiosemicarbazides

On a four series of 1-azolil-4-aryl/alkyl-thiosemicabazides, a study on the influence of azole moiety on the capability for intramolecular cyclization and its direction was carried out. It was found that for 4-aryl/alkyl- thiosemicabazides with triazole, imidazole, or pyrrole moiety at N-1 nitrogen atom possible products were only s-triazoles, both in alkaline and acidic medium. Successful dehydrocyclization of 1-azolil-4-aryl/alkyl- thiosemicarbazides leading to a thiadiazole has been documented only for a series of 1-(4-methyl-1,2,3-thiadiazol-5-yl-carbonyl)-4-aryl/alkyl- thiosemicarbazides. It can be speculative that the determination of pK a value of oxygen atom of 1-azolil-4-aryl/alkyl-thiosemicarbazide can be a very valuable parameter in the prediction of the possibility of dehydrocyclization to form thiadiazole.