1260403-07-3Relevant articles and documents
Asymmetric Synthesis of 2,3-Dihydrobenzofurans by a [4+1] Annulation Between Ammonium Ylides and In Situ Generated o-Quinone Methides
Meisinger, Nicole,Roiser, Lukas,Monkowius, Uwe,Himmelsbach, Markus,Robiette, Rapha?l,Waser, Mario
, p. 5137 - 5142 (2017)
A highly enantio- and diastereoselective [4+1] annulation between in situ generated ammonium ylides and o-quinone methides for the synthesis of a variety of 2,3-dihydrobenzofurans has been developed. The key factors controlling the reactivity and stereoselectivity were systematically investigated by experimental and computational means and the energy profiles obtained provide a deeper insight into the mechanistic details of this reaction.