1260489-49-3Relevant academic research and scientific papers
Discovery of (7 R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase
Narjes, Frank,Crescenzi, Benedetta,Ferrara, Marco,Habermann, J?rg,Colarusso, Stefania,Del Rosario Rico Ferreira, Maria,Stansfield, Ian,MacKay, Angela Claire,Conte, Immacolata,Ercolani, Caterina,Zaramella, Simone,Palumbi, Maria-Cecilia,Meuleman, Philip,Leroux-Roels, Geert,Giuliano, Claudio,Fiore, Fabrizio,Di Marco, Stefania,Baiocco, Paola,Koch, Uwe,Migliaccio, Giovanni,Altamura, Sergio,Laufer, Ralph,De Francesco, Raffaele,Rowley, Michael
, p. 289 - 301 (2011/03/22)
Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand. The polymerase of HCV is responsible for the replication of viral genome and has been a prime target for drug discovery eff
