1260612-08-5 Usage
Description
Tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate is a fluorinated piperidine derivative with the molecular formula C11H20FN3O2. It is a chemical compound that serves as a building block in the synthesis of pharmaceutical drugs and other organic compounds. The presence of a tert-butyl group attached to the nitrogen atom provides stability and steric hindrance, while the amino and fluorine functional groups make it potentially useful for medicinal chemistry applications. tert-butyl (3R,4R)-4-aMino-3-fluoropiperidine-1-carboxylate is an important intermediate for the synthesis of various pharmaceuticals and organic molecules.
Uses
Used in Pharmaceutical Industry:
Tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate is used as a key intermediate in the synthesis of pharmaceutical drugs. Its unique structure, including the tert-butyl group, amino, and fluorine functional groups, makes it a valuable building block for the development of new medications with improved properties.
Used in Organic Synthesis:
In the field of organic synthesis, tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate is used as a versatile starting material for the preparation of various organic compounds. Its reactivity and functional group compatibility make it suitable for a wide range of synthetic transformations, enabling the creation of diverse chemical libraries.
Used in Medicinal Chemistry Research:
Tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate is employed as a research tool in medicinal chemistry. Its unique structural features and potential for functionalization make it an attractive candidate for the design and synthesis of novel bioactive compounds, contributing to the discovery of new therapeutic agents and probes for biological studies.
Check Digit Verification of cas no
The CAS Registry Mumber 1260612-08-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,0,6,1 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1260612-08:
(9*1)+(8*2)+(7*6)+(6*0)+(5*6)+(4*1)+(3*2)+(2*0)+(1*8)=115
115 % 10 = 5
So 1260612-08-5 is a valid CAS Registry Number.
1260612-08-5Relevant articles and documents
Synthesis of a CGRP Receptor Antagonist via an Asymmetric Synthesis of 3-Fluoro-4-aminopiperidine
Molinaro, Carmela,Phillips, Eric M.,Xiang, Bangping,Milczek, Erika,Shevlin, Michael,Balsells, Jaume,Ceglia, Scott,Chen, Jiahui,Chen, Lu,Chen, Qinghao,Fei, Zhongbo,Hoerrner, Scott,Qi, Ji,De Lera Ruiz, Manuel,Tan, Lushi,Wan, Baoqiang,Yin, Jingjun
, p. 8006 - 8018 (2019/06/17)
A practical and efficient enantioselective synthesis of the calcitonin gene-related peptide receptor antagonist 1 has been developed. The key structural component of the active pharmaceutical ingredient is a syn-1,2-amino-fluoropiperidine 4. Two approaches were developed to synthesize this important pharmacophore. Initially, Ru-catalyzed asymmetric hydrogenation of fluoride-substituted enamide 8 enabled the synthesis of sufficient quantities of compound 1 to support early preclinical studies. Subsequently, a novel, cost-effective route to this intermediate was developed utilizing a dynamic kinetic asymmetric transamination of ketone 9. This synthesis also features a robust Ullmann coupling to install a bis-aryl ether using a soluble Cu(I) catalyst. Finally, an enzymatic desymmetrization of meso-diester 7 was exploited for the construction of the γ-lactam moiety in 1.
COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK
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, (2015/02/25)
The present invention relates to compounds of formula I in which n, R1, R2, R3a, R4 and R5 are defined in the Summary of the Invention; capable of inhibiting the activity of MEK. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of hyperproliferative diseases like cancer.