373604-28-5

Basic information

• Product Name: 1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER
• Synonyms: 1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER;tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate;benzyl 3-fluoro-4-hydro×ypiperidine-1-carbo×ylate;tert-butyl 3-fluoro-4-hydro×ypiperidine-1-carbo×ylate;3-Fluoro-4-hydroxy-1-piperidinecarboxylic Acid 1,1-DiMethylethyl Ester;3-Fluoro-4-hydroxy-1-piperidinecarboxylic Acid tert-Butyl Ester (Mixture of DiastereoMers);3-Fluoro-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;(3.4)-cis-3-FLUORO-4-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS NO: 373604-28-5
• Molecular Formula: C₁₀H₁₈FNO₃
• Molecular Weight: 219.254
• Mol File: 373604-28-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 300.795 °C at 760 mmHg
• Flash Point: 135.717 °C
• Appearance: /
• Density: 1.156 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER(373604-28-5)
• EPA Substance Registry System: 1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER(373604-28-5)

Safety Data

• Hazardous Substances Data: 373604-28-5(Hazardous Substances Data)

Usage

Uses

3-Fluoro-4-hydroxy-1-piperidinecarboxylic Acid tert-Butyl Ester is used in the preparation of therapeutic GPR 119 modulators.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 211108-48-4 tert-butyl 4-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate 
• 211108-50-8 tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate 

Downstream Products

• 1070896-84-2 (anti)-3-fluoro-4-methanesulfonyloxypiperidine-1-carboxylic acid tert-butyl ester 
• 577691-56-6 cis-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate 
• 1070896-84-2 tert-butyl 3-fluoro-4-((methylsulfonyl)oxy)piperidine-1-carboxylate 
• 1450879-65-8 tert-butyl (3R,4S)-3-fluoro-4-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate 
• 1450879-66-9 (3S,4R)-tert-butyl 3-fluoro-4-(tosyloxy)piperidine-1-carboxylate 
• 577691-56-6 (3S,4S)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate 
• 1260612-08-5 (3R,4R)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate 
• 211108-52-0 (3S,4S)-tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate 
• 211108-52-0 (3R,4R)-tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate 
• 934536-09-1 tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate 

Relevant articles and documents

SPIRO[CYCLOBUTANE-1,3'-INDOLIN]-2'-ONE DERIVATIVES AS BROMODOMAIN INHIBITORS

The present invention provides novel spiro[cyclobutane-1,3'-indolin]-2'- derivatives of formula (I) in which Cy R1, R2, R4, L and 'm' are have the meaning given in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful as bromodomain inhibitors in the treatment or prevention of diseases or disorders where bromodomain inhibition is desired.

COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK

The present invention relates to compounds of formula I: in which n, R1, R2, R3a, R4 and R5 are defined in the Summary of the Invention; capable of inhibiting the activity of MEK. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of hyperproliferative diseases like cancer.

BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.