126079-16-1

Basic information

• Product Name: Glycine, N-[(4-methoxyphenyl)methylene]-, methyl ester
• CAS NO: 126079-16-1
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.229
• Mol File: 126079-16-1.mol
• Article Data: 52

Chemical Properties

• CAS DataBase Reference: Glycine, N-[(4-methoxyphenyl)methylene]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[(4-methoxyphenyl)methylene]-, methyl ester(126079-16-1)
• EPA Substance Registry System: Glycine, N-[(4-methoxyphenyl)methylene]-, methyl ester(126079-16-1)

Safety Data

• Hazardous Substances Data: 126079-16-1(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 616-34-2 methoxycarbonylmethylamine 
• 5680-79-5 glycine ethyl ester hydrochloride 

Downstream Products

• 126079-20-7 (3aR,5R,6aS)-5-(4-Methoxy-phenyl)-1,1-dioxo-hexahydro-1λ⁶-thieno[3,2-b]pyrrole-3a-carboxylic acid methyl ester 
• 20839-80-9 (4-methoxybenzylamino)acetic acid methyl ester 
• 872848-25-4 [3-(4-methoxy-phenyl)-oxaziridin-2-yl]-acetic acid methyl ester 
• 1040185-06-5 (2R,3S,4S,5S)-methyl 5-(p-methoxyphenyl)-3,4-bis(phenylsulfonyl)pyrrolidine-2-carboxylate 
• 1100793-06-3 (1S,3R,3aS,6aR)-methyl octahydro-3-(p-methoxyphenyl)-4-oxocyclopenta[c]pyrrole-1-carboxylate 
• 1100793-63-2 (2S,3S,4R,5R)-methyl 4-benzoyl-3-phenyl-5-(p-methoxyphenyl)pyrrolidine-2-carboxylate 

Relevant articles and documents

Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions

In dynamic covalent chemistry, reactions follow a thermodynamically controlled pathway through equilibria. Reversible covalent-bond formation and breaking in a dynamic process enables the interconversion of products formed under kinetic control to thermod

Copper/GanPhos-Catalyzed 1,3-Dipolar Cycloaddition of Azo?-methine Ylides: An Efficient Access to Chiral Pyrrolidine Spirocycles

A highly efficient copper/GanPhos-catalyzed 1,3-dipolar cyclo?-addition?-of azomethine ylides is reported. This viable transformation provides a series of optically active spiro[dihydronaphthalene-2,3′-pyrrolidine]s, bearing one spiro quaternary and three tertiary stereogenic centers, in good yields and with high ee values. This protocol features high diastereo- A nd enantioselectivity, broad substrate scope and mild reaction conditions.

Boron Dipyrromethene (BODIPY) as Electron-Withdrawing Group in Asymmetric Copper-Catalyzed [3+2] Cycloadditions for the Synthesis of Pyrrolidine-Based Biological Sensors

In this work, we describe the use of Boron Dipyrromethene (BODIPY) as electron-withdrawing group for activation of double bonds in asymmetric copper-catalyzed [3+2] cycloaddition reactions with azomethine ylides. The reactions take place under smooth conditions and with high enantiomeric excess for a large number of different substituents, pointing out the high activation of the alkene by using a boron dipyrromethene as electron-withdrawing group. Experimental, theoretical studies and comparison with other common electron-withdrawing groups in asymmetric copper-catalyzed [3+2] cycloadditions show the reasons of the different reactivity of the boron dipyrromethene derivatives, which can be exploited as a useful activating group in asymmetric catalysis. Additional experiments show that the so obtained pyrrolidines can be employed as biocompatible biosensors, which can be located in the endosomal compartments and do not present toxicity in three cell lines. (Figure presented.).