1260868-75-4Relevant academic research and scientific papers
Concise synthesis of tetrahydropyrans by a tandem oxa-michael/tsuji-trost reaction
Wang, Liang,Li, Pengfei,Menche, Dirk
, p. 9270 - 9273 (2010)
A novel domino sequence facilitates the rapid assembly of polysubstituted tetrahydropyrans. The one-pot relay process generates up to three new stereogenic centers, including a tetrasubstituted carbon center, in a highly concise and convergent fashion from simple starting materials. Copyright
Construction of multisubstituted tetrahydropyrans by a domino oxa-michael/tsujia-trost reaction
Wang, Liang,Menche, Dirk
, p. 10811 - 10823 (2013/02/22)
Biologically significant tetrahydropyrans (THP) were synthesized by a Tandem oxa-Michael/Tsujia-Trost reaction. Different Michael acceptors were investigated, and optimal results in terms of diastereoselectivities and yields were obtained with nitro olefins. The influence of the reaction parameters, substrate patterns, and type of metal counterions on the yield and stereochemical outcome of this process is discussed, and an explanation for the observed stereoselectivities is proposed.
