1260868-82-3Relevant academic research and scientific papers
Stereoselective synthesis of 1,3-amino alcohols by the Pd-catalyzed cyclization of trichloroacetimidates
Xie, Yuanzhen,Yu, Kai,Gu, Zhenhua
, p. 1289 - 1302 (2014/03/21)
The synthesis of 4-vinyl-5,6-dihydro-1,3-oxazines, precursors of 1,3-amino alcohols, using the palladium-catalyzed cyclization of trichloroacetimidates is reported. The reaction favors the formation of the 4,6-cis-isomers with up to >20:1 diastereoselecti
Construction of multisubstituted tetrahydropyrans by a domino oxa-michael/tsujia-trost reaction
Wang, Liang,Menche, Dirk
, p. 10811 - 10823 (2013/02/22)
Biologically significant tetrahydropyrans (THP) were synthesized by a Tandem oxa-Michael/Tsujia-Trost reaction. Different Michael acceptors were investigated, and optimal results in terms of diastereoselectivities and yields were obtained with nitro olefins. The influence of the reaction parameters, substrate patterns, and type of metal counterions on the yield and stereochemical outcome of this process is discussed, and an explanation for the observed stereoselectivities is proposed.
Concise synthesis of tetrahydropyrans by a tandem oxa-michael/tsuji-trost reaction
Wang, Liang,Li, Pengfei,Menche, Dirk
, p. 9270 - 9273 (2011/02/28)
A novel domino sequence facilitates the rapid assembly of polysubstituted tetrahydropyrans. The one-pot relay process generates up to three new stereogenic centers, including a tetrasubstituted carbon center, in a highly concise and convergent fashion from simple starting materials. Copyright
