1261242-23-2

Basic information

• Product Name: 1-(2-(4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea
• Synonyms: 1-(2-(4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea
• CAS NO: 1261242-23-2
• Molecular Weight: 473.534
• Mol File: 1261242-23-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2-(4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea(1261242-23-2)
• EPA Substance Registry System: 1-(2-(4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea(1261242-23-2)

Safety Data

• Hazardous Substances Data: 1261242-23-2(Hazardous Substances Data)

Upstream product

• 103-71-9 phenyl isocyanate 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 7025-29-8 6-p-fluorophenylimidazo<2,1-b>thiazole 
• 151093-41-3 α-bromo-4-fluoroacetophenone 
• 815595-78-9 6-(4-fluorophenyl)-5-(2-(methylsulfonyl)pyrimidin-4-yl)imidazo[2,1-b]thiazole 
• 53673-01-1 1-(2-aminoethyl)-3-phenylurea 
• 815595-77-8 6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole 
• 1261242-10-7 benzyl 2-(3-phenylureido)ethylcarbamate 

Relevant articles and documents

Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies

A series of imidazothiazole derivatives possessing potential activity against melanoma cells were investigated for molecular mechanism of action. The target compounds were tested against V600E-B-RAF and RAF1 kinases. Compound 1zb is the most potent agains

Synthesis of new 6-(4-Fluorophenyl)-5-(2-substituted pyrimidin-4-yl) imidazo[2,1-b] thiazole derivatives and their antiproliferative activity against melanoma cell line

Synthesis of a new series of pyrimidinyl-imidazo[2,1-b]thiazole derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the pyrimidinyl ring side chain was investigated.