1261244-46-5Relevant articles and documents
Synthesis and biological evaluation of retinoid-chalcones as inhibitors of colon cancer cell growth
Mizuno, Cassia S.,Paul, Shiby,Suh, Nanjoo,Rimando, Agnes M.
supporting information; experimental part, p. 7385 - 7387 (2011/02/23)
Based on the observed anticancer activity of chalcones and retinoids, a novel class of retinoid-chalcone hybrids was designed and synthesized. As part of our ongoing studies to discover natural product based anticancer compounds, the retinoid-chalcone hybrids were tested against the colon cancer cell line HT-29. Retinoid like moiety was introduced through Friedel-Crafts alkylation of toluene. Among the synthesized compounds, the cyano derivative (E)-3-(3-oxo-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl) prop-1-enyl)benzonitrile 8 showed submicromolar inhibitory activity with an IC50 of 0.66 μM.