126135-39-5

Upstream product

• 186581-53-3 diazomethane 
• 63639-61-2 4-hydroxy-4-(4-methoxy-phenyl)-butyric acid 
• 5447-74-5 methyl 3-(4-methoxybenzoyl)propionate 
• 3153-44-4 4-(4-methoxy-phenyl)-4-oxo-butyric acid 
• 100-66-3 methoxybenzene 

Downstream Products

• 26153-41-3 γ-(4-methoxyphenyl)-γ-butyrolactone 
• 128994-28-5 (S)-(-)-γ-(p-Methoxyphenyl)-γ-butyrolactone 
• 126135-42-0 (R)-(+)-γ-(p-Methoxyphenyl)-γ-butyrolactone 
• 118528-01-1 dihydro-4-[(4-methoxyphenyl)methyl]-2(3H)-furanone 
• 30088-33-6 3-(4-methoxyphenyl)methyl-2-buten-1,4-olide 
• 5447-74-5 methyl 3-(4-methoxybenzoyl)propionate 

Relevant academic research and scientific papers

Novel chemo-enzymatic process for the preparation of opticaly enriched beta-benzyl-gamma-butyrolactones

The present invention relates to a novel process for the preparation of optically enriched substituted R(+)β-benzyl-γ-butyrolactones of the general formula 1, 1wherein, R1 and R2 independently represent the following groups, R1=R2=H, OH, —OCnH2n+1 (n=1 to 8), NH2, and/or CF3, R1 and R2 together represents —O(CH2)mO— where m=2 to 4.

New chemo and chemo-enzymatic synthesis of β-benzyl-γ-butyrolactones

β-Benzyl-γ-butyrolactones, important intermediates for the synthesis of butyrolactone lignans, have been synthesized by a new route involving preparation of α-β-unsaturated formyl esters. The formyl esters can easily be converted into the desired butyrolactones either through chemical transformations or by enzymatic methods.

Process for the stereoselective reduction of derivatives of 4-aryl-4-oxobutyric acid

A method for the stereoselective production of 4-aryl-4-hydroxybutanoic acid derivatives involves reduction of the corresponding 4-keto-acid derivative with formic acid and/or formates in presence of a ruthenium-containing catalyst and amine(s). A method

Lipase-Catalyzed Preparation of Optically Active γ-Butyrolactones in Organic Solvents

Lipases in anhydrous organic solvents catalyze the lactonization of esters of γ-hydroxy carboxylic acids with a high degree of stereospecifity.Under these conditions the lipases exhibit both enantioselectivity and prochiral selectivity.We exploited the enzymes' enantioselectivity for synthesis of chiral lactones from racemic γ-hydroxy esters and their prochiral stereospecifity, i.e. the ability to discriminate between enantiotopic groups of a prochiral molecule, for the enantioconvergent lactonization of symmetrical γ-hydroxy diesters.This approach was used to develop a convenient, high yielding, and stereoselective route to several optically active γ-substituted γ-butyrolactones.