128994-28-5

Basic information

• Product Name: 2(3H)-Furanone, dihydro-5-(4-methoxyphenyl)-, (5S)-
• CAS NO: 128994-28-5
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Mol File: 128994-28-5.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 2(3H)-Furanone, dihydro-5-(4-methoxyphenyl)-, (5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, dihydro-5-(4-methoxyphenyl)-, (5S)-(128994-28-5)
• EPA Substance Registry System: 2(3H)-Furanone, dihydro-5-(4-methoxyphenyl)-, (5S)-(128994-28-5)

Safety Data

• Hazardous Substances Data: 128994-28-5(Hazardous Substances Data)

Upstream product

• 52498-02-9 3-(p-methoxyphenyl)cyclobutanone 
• 1379829-57-8 C₃₂H₄₀O₅ 
• 5447-74-5 methyl 3-(4-methoxybenzoyl)propionate 
• 1010800-67-5 tert-butyl 4-(4-methoxyphenyl)-4-oxobutanoate 
• 3153-44-4 4-(4-methoxy-phenyl)-4-oxo-butyric acid 
• 1304688-94-5 (S)-tert-butyl 4-hydroxy-4-(4-methoxyphenyl)butanoate 
• 4586-89-4 ethyl 4-(4-methoxyphenyl)butanoate 
• 5711-41-1 3-(4-methoxybenzoyl)acrylic acid 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 34910-42-4 1-(1-azidovinyl)-4-methoxybenzene 
• 58688-30-5 α-(4-methoxybenzoyl)-γ-butyrolactone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 27364-22-3 4-hydroxy-1-(4-methoxyphenyl)-butan-1-one 
• 1020690-40-7 (S)-3-(4'-methoxybenzoyl)-N-(α-phenylethyl)propanamide 

Relevant articles and documents

Asymmetric H2O-Nucleophilic Ring Opening of D-A Cyclopropanes: Catalyst Serves as a Source of Water

The first catalytic enantioselective ring-opening reaction of donor-acceptor cyclopropanes with water is described. By employing Cy-TOX/Cu(II) as catalyst, the reaction performed very well over a broad range of substrates, leading to the ring-opening products in 70-96% yields with up to 95% ee under mild conditions. The current method provides a new approach to direct access to γ-substituted GBH derivatives very efficiently. Importantly, Cu(ClO4)2·6H2O proves to serve as both a Lewis acid and a source of water, which affords a fine system to controllably release water as a nucleophile in the asymmetric catalysis.

Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations

Chemical transformations that install heteroatoms into C?H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C?H oxyfunctionalization, or the one step conversion of a C?H bond to a C?O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C?H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.

Synthesis of chiral γ-lactones via a RuPHOX-Ru catalyzed asymmetric hydrogenation of aroylacrylic acids

An asymmetric hydrogenation of aroylacrylic acids catalyzed by RuPHOX-Ru catalyst has been developed, affording the corresponding chiral γ-lactones in high yields and with up to 93% ee. The methodology has the advantage of utilizing easily accessible substrates and has therefore expand the scope of the resulting chiral γ-lactones. Furthermore, high catalytic efficiency was achieved in that the reduction of both the C[dbnd]C and C[dbnd]O double bonds was achieved in one step. The current work provides an alternative and convenient pathway for the synthesis of a wide range of chiral γ-lactones.