126147-81-7

Upstream product

• 67-56-1 methanol 
• 32025-65-3 3-methoxyphenylglyoxal 
• 1154193-05-1 2-(3-methoxyphenoxy)-1-(3-methoxyphenyl)ethanone 
• 26870-30-4 1-(3-methoxyphenyl)-2-phenoxyethan-1-one 
• 1401816-27-0 N-trimethoxy-N-methyl-acetamide 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 

Downstream Products

• 83585-22-2 methyl 2-(3-methoxyphenyl)-2-oxoacetate 
• 126147-82-8 [(R)-2,2-Dimethoxy-1-(3-methoxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine 
• 126147-83-9 (R,R)-2,2-Dimethoxy-1-(3-methoxyphenyl)-N-(1-phenylethyl)ethylamine 
• 126147-82-8 (S,S)-2,2-Dimethoxy-1-(3-methoxyphenyl)-N-(1-phenylethyl)ethylamine 
• 126147-82-8 [(S)-2,2-Dimethoxy-1-(3-methoxy-phenyl)-ethyl]-((R)-1-phenyl-ethyl)-amine 
• 126147-85-1 (R)-2,2-Dimethoxy-1-(3-methoxyphenyl)ethylamine 
• 126147-84-0 (S)-2,2-Dimethoxy-1-(3-methoxyphenyl)ethylamine 

Relevant academic research and scientific papers

Cu-catalyzed aerobic oxygenation of 2-phenoxyacetophenones to alkyloxy acetophenones

Cu-catalyzed aerobic oxygenation of 2-phenoxyacetophenones in the presence of alcohols was reported, and the corresponding alkyl benzoates, alkyloxy acetophenones and phenols were produced in high yields.

Iridium-Catalyzed Asymmetric Hydrogenation of Unsaturated Piperazin-2-ones

Two different iridium catalyst systems, generated from the ruthenocene-based phosphine-oxazoline ligand tBu-mono-RuPHOX or the diphosphine ligand BINAP, were developed for the asymmetric hydrogenation of 5,6-dihydropyrazin-2(1H)-ones, affording chiral piperazin-2-ones in good yields and with moderate to good ees. Different catalytic behaviors for the hydrogenation of these types of substrate were observed with these two catalyst systems. Our tBu-mono-RuPHOX ligand, which bears a ruthenocene scaffold with planar chirality, was found to be the best ligand for the [Ir(L)(COD)]BArF catalyst system, affording the desired products with up to 94% ee. (Figure presented.).

Efficient preparation of α-ketoacetals

The Weinreb amides 2a,b were prepared from the a,a-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded a-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.