32025-65-3

Usage

Uses

Used in Pharmaceutical Industry:
3-Methoxyphenylglyoxal hydrate is used as an intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the creation of complex organic compounds.
Used in Organic Chemistry:
3-Methoxyphenylglyoxal hydrate is used as a reagent in chemical reactions, particularly for the preparation of heterocyclic compounds, which are important in the development of various organic compounds.
Used in Dye and Pigment Manufacturing:
3-Methoxyphenylglyoxal hydrate is used in the manufacturing of dyes and pigments, contributing to the coloration and properties of these products.
Used in Research and Development:
3-Methoxyphenylglyoxal hydrate is utilized in the research and development of new drugs and pharmaceuticals, leveraging its unique chemical properties to explore novel therapeutic agents and applications.

InChI:InChI=1/C9H8O3/c1-12-8-4-2-3-7(5-8)9(11)6-10/h2-6H,1H3

Upstream product

• 5000-65-7 2-bromo-3'-methoxyacetophenone 
• 87428-52-2 2-hydroxy-3'-methoxyacetophenone 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 121041-16-5 3-methoxy-6-(3'-methoxybenzylthio)-2-(3''-methoxyphenyl)imidazo<1,2-b>pyridazine 
• 121247-05-0 6-chloro-3-methoxy-2-(3'-methoxyphenyl)imidazo<1,2-b>pyridazine 
• 69467-02-3 5-(3-methoxyphenyl)-3-(methylthio)-1,2,4-triazine 
• 1227411-40-6 3-(1-hydroxy-2-(3-methoxyphenyl)-2-oxoethyl)-3-methylindolin-2-one 
• 1237514-13-4 acetic acid 1-(1,5-dichloro-10-oxo-9,10-dihydro-anthracen-9-yl)-2-(3-methoxy-phenyl)-2-oxo-ethyl ester 
• 1253392-55-0 6-(3-methoxyphenyl)-4-cyano-3(2H)-pyridazinone 
• 1253392-59-4 5-(3-methoxyphenyl)-4-cyano-3(2H)-pyridazinone 
• 32345-63-4 1-(3-methoxyphenyl)-1,2-ethanediol 
• 329346-52-3 (S)-1-(m-methoxy phenyl)ethane-1,2-diol 
• 1352240-98-2 3-[2-(3-methoxy-phenyl)-2-oxo-ethylidene]-1-phenyl-pyrrolidine-2,5-dione 
• 1403356-72-8 3-chloro-2-(3-methoxyphenyl)-4H-furo[3,2-c]chromen-4-one 
• 1435901-77-1 1-benzamido-2-(3-methoxyphenyl)naphtho[2,1-b]furan 

Relevant academic research and scientific papers

Synthesis of α-keto aldehydes via selective Cu(i)-catalyzed oxidation of α-hydroxy ketones

An efficient approach to synthesize α-keto aldehydes was established through selective oxidation of α-hydroxy ketones catalyzed by Cu(i) using oxygen as oxidant. A wide array of α-keto aldehydes was prepared with isolated yields of up to 87%. The potential utilization of this reaction was evaluated by gram-scale reactions and synthetic applications.

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues. Effect of the stereochemistry of the phenylpiperazine moiety is also discussed.

[1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE COMPOUND, PREPARATION METHOD AND USE THEREOF

The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compounds represented by formula (I) or formula (II), pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates or solvates thereof, and also relates to a preparation method of the compounds, a pharmaceutical composition comprising a therapeutically effective amount of the compounds, as well as the use thereof as protein tyrosine kinase inhibitors, particularly as c-Met inhibitors, in the preparation of medicaments for the prevention and/or treatment of diseases associated with c-Met abnormality.