126149-53-9Relevant academic research and scientific papers
Synthesis and structure-activity relationships of 4-oxo-1-phenyl- 3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: Novel PDE4 inhibitors
Pascal, Yves,Andrianjara, Charles R.,Auclair, Eric,Avenel, Nadine,Bertin, Bernadette,Calvet, Alain,Feru, Frederic,Lardon, Sophie,Moodley, Indres,Ouagued, Malika,Payne, Adrian,Pruniaux, Marie-Pierre,Szilagyi, Corinne
, p. 35 - 38 (2007/10/03)
A novel series of benzodiazepine derivatives have been discovered as inhibitors of PDE4 enzymes. We have found that our compounds are selective versus other PDE enzymes, and that the activity can be modulated by specific structural modifications. One compound exhibited a strong eosinophilic infiltration inhibiting action on sensitized Brown-Norway rats (compound 9, 5.1 mg/kg p.o.), moreover this compound is not emetic at 3 mg/kg i.v.
Studies on a novel, potent and orally effective cholecystokinin A antagonist, FK-480. Synthesis and structure-activity relationships of FK-480 and related compounds
Satoh,Matsuo,Sogabe,Itoh,Tada,Kinoshita,Yoshida,Takaya
, p. 2071 - 2083 (2007/10/02)
We prepared various novel tricyclic 1,4-benzodiazepine derivatives as cholecystokinin (CCK) A antagonists, which were evaluated preliminarily for inhibition of 125I-CCK-8 binding to rat pancreatic membranes in vitro and inhibiting effect on CCK
