126150-65-0

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 123-31-9 hydroquinone 

Downstream Products

• 59893-20-8 O-ethyl O-[4-(methanesulfonyloxy)phenyl] S-n-propyl phosphorodithioate 
• 74-31-7 N,N'-diphenyl-1,4-phenylenediamine 
• 123-31-9 hydroquinone 
• 133155-29-0 1-(4-methanesulphonyloxy-phenoxy)-2,3-epoxypropane 
• 59722-33-7 p-(methanesulfonyloxy)phenol 

Relevant academic research and scientific papers

Selected sulfonyl compounds as anticancer/antimalarial agents

The synthesis and biological testing of a series of sulfonyl phenols and sulfonyl aryl methyl ethers has revealed that p-methoxyphenyl p-toluenesulfonate is a very selective and effective antimalarial agent which shows pronounced activity against human skin cancer cells. Application of a counter-attack strategy permits the direct preparation of the requisite tosylate ether from the bis(tosylate) of dihydroquinone.

Chromatography-Free and Eco-Friendly Synthesis of Aryl Tosylates and Mesylates

Two chromatography-free and eco-friendly protocols have been developed to synthesize aryl tosylates and mesylates by the tosylation and mesylation of the corresponding hydroxyarenes, respectively. These protocols are superior to other known ones regarding

Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity

The possible sulfatase activity of several carbonic anhydrase (CA, EC 4.2.1.1) isoforms have been investigated with a series of synthesized methanesulfonate derivatives of phenols. Four α-CA isozymes, i.e. hCA I, hCA II, hCA IV and hCA VI (h=human isoform), were included in the study. We evidenced that the original sulfonate esters are being hydrolyzed effectively to the corresponding phenols which there after act as CA inhibitors. The KI-s of these compounds ranged from 10.24 to 4012 μM against hCA I, 0.10 to 35.42 μM against hCA II, 0.49 to 45.06 μM against hCA IV and 3.27 to 608 μM against CA VI, respectively. The relevant sulfatase activity of CA with these esters is amazing considering the fact that 4-nitrophenyl-sulfate, an activated ester, is not a substrate of these enzymes.